The monitoring of antiaggregation effect of acetylsalicylic acid therapy by measuring serum thromboxane B2 in patients with coronary artery bypass grafting (CROSBI ID 277387)
Prilog u časopisu | ostalo | međunarodna recenzija
Podaci o odgovornosti
Klasic, Anita ; Lakusic, Nenad ; Hospital for Medical Rehabilitation Krapinske Toplice, Faculty of Medicine Osijek, J. J. Strossmayer University of Osijek ; Gaspar, Ludovit ; Kruzliak, Peter
engleski
The monitoring of antiaggregation effect of acetylsalicylic acid therapy by measuring serum thromboxane B2 in patients with coronary artery bypass grafting
Cardiovascular patients take acetylsalicylic acid (ASA) for preventing myocardial infarction and other thromboembolic complications. It is already known that in some patients this therapy is not effective. The aim of this study was to assess the percentage of ASA resistance on the sample of patients with coronary artery bypass grafting. Our study included 105 patients with coronary artery bypass grafting treated with ASA 150 mg/day or lesser. Platelet aggregation was measured by serum thromboxane B2 level as well as impedance aggregometry from whole blood to determine ASA antiaggregation effect. The percentage of ASA resistance was 41.9% with impedance aggregometry, and after determining the serum thromboxane B2 level this percentage was only 8.6%. The correlation between these two methods was weak (r = 0.443 ; P < 0.0001). Thromboembolic complications still occur in ASA-treated patients because some patients are resistant to ASA therapy. It would be useful to monitor the effectiveness of ASA therapy and give another antiaggregation drug to these patients to reduce adverse events. The problem is which test is ideal because different tests show different percentages of ASA resistance.
antiaggregation, acetylsalicylic acid, thromboxane B2, coronary artery bypass
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Podaci o izdanju
27 (4)
2016.
370-373
objavljeno
0957-5235
10.1097/mbc.0000000000000438
Povezanost rada
Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)