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Pregled bibliografske jedinice broj: 1058068

Association of bacterial load in drinking water and allergic diseases in childhood


Turkalj, Mirjana; Drkulec, Vlado; Haider, Sadia; Plavec, Davor; Banić, Ivana; Malev, Olga; Erceg, Damir; Woodcock, Ashley; Nogalo, Boro; Custovic, Adnan
Association of bacterial load in drinking water and allergic diseases in childhood // Clinical and experimental allergy, 50 (2020), 13605, 5 doi:10.1111/cea.13605 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1058068 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Association of bacterial load in drinking water and allergic diseases in childhood
(Association of bacterial load in drinking water and allergic diseases in childhood.)

Autori
Turkalj, Mirjana ; Drkulec, Vlado ; Haider, Sadia ; Plavec, Davor ; Banić, Ivana ; Malev, Olga ; Erceg, Damir ; Woodcock, Ashley ; Nogalo, Boro ; Custovic, Adnan

Izvornik
Clinical and experimental allergy (0954-7894) 50 (2020); 13605, 5

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
atopy ; bacterial load ; children ; drinking water ; microbiota ; well water

Sažetak
BACKGROUND: Treatment of drinking water may decrease microbial exposure. OBJECTIVE: To investigate whether bacterial load in drinking water is associated with altered risk of allergic diseases. METHODS: We recruited 1, 110 schoolchildren aged 6-16 years between 2011 and 2013 in Požega-Slavonia County in Croatia, where we capitalized on a natural experiment whereby individuals receive drinking water through public mains supply or individual wells. We obtained data on microbial content of drinking water for all participants ; 585 children were randomly selected for more detailed assessments, including skin prick testing. Since water supply was highly correlated with rural residence, we compared clinical outcomes across four groups (Rural/Individual, Rural/Public, Urban/Individual, Urban/Public). For each child, we derived quantitative index of microbial exposure (bacterial load in the drinking water measured during the child's first year of life). RESULTS: Cumulative bacterial load in drinking water was higher (median [IQR]: 6390 [4190-9550] vs. 0 [0-0] ; p<0.0001), and lifetime prevalence of allergic diseases was significantly lower among children with individual supply (5.5% vs. 2.3%, p=0.01 ; 14.4% vs. 6.7%, p<0.001 ; 25.2 vs. 15.1%, p<0.001 ; asthma, atopic dermatitis [AD] and rhinitis respectively). Compared with the reference group (Urban/Public), there was a significant reduction in the risk of ever asthma, AD and rhinitis amongst rural children with individual supply: OR [95% CI]: 0.14 [0.03, 0.67], p=0.013 ; 0.20 [0.09, 0.43], p <0.001 ; 0.17 [0.10, 0.32], p<0.001. Protection was also observed in the Rural/Public group, but the effect was consistently highest among Rural/Individual children. In the quantitative analysis, the risk of allergic diseases decreased significantly with increasing bacterial load in drinking water in the first year of life (0.79 [0.70, 0.88], p<0.001 ; 0.90 [0.83, 0.99], p=0.025 ; 0.80 [0.74, 0.86], p<0.001 ; current wheeze, AD and rhinitis). CONCLUSIONS: High commensal bacterial content in drinking water may protect against allergic diseases. This article is protected by copyright. All rights reserved.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove:
Prirodoslovno-matematički fakultet, Zagreb,
Medicinski fakultet, Osijek,
Dječja bolnica Srebrnjak,
Opća županijska bolnica Požega,
Hrvatsko katoličko sveučilište, Zagreb

Profili:

Avatar Url Olga Malev (autor)

Avatar Url Boro Nogalo (autor)

Avatar Url Damir Erceg (autor)

Avatar Url Mirjana Turkalj (autor)

Avatar Url Vlado Drkulec (autor)

Avatar Url Ivana Banić (autor)

Avatar Url Davor Plavec (autor)

Citiraj ovu publikaciju

Turkalj, Mirjana; Drkulec, Vlado; Haider, Sadia; Plavec, Davor; Banić, Ivana; Malev, Olga; Erceg, Damir; Woodcock, Ashley; Nogalo, Boro; Custovic, Adnan
Association of bacterial load in drinking water and allergic diseases in childhood // Clinical and experimental allergy, 50 (2020), 13605, 5 doi:10.1111/cea.13605 (međunarodna recenzija, članak, znanstveni)
Turkalj, M., Drkulec, V., Haider, S., Plavec, D., Banić, I., Malev, O., Erceg, D., Woodcock, A., Nogalo, B. & Custovic, A. (2020) Association of bacterial load in drinking water and allergic diseases in childhood. Clinical and experimental allergy, 50, 13605, 5 doi:10.1111/cea.13605.
@article{article, year = {2020}, pages = {5}, DOI = {10.1111/cea.13605}, chapter = {13605}, keywords = {atopy, bacterial load, children, drinking water, microbiota, well water}, journal = {Clinical and experimental allergy}, doi = {10.1111/cea.13605}, volume = {50}, issn = {0954-7894}, title = {Association of bacterial load in drinking water and allergic diseases in childhood}, keyword = {atopy, bacterial load, children, drinking water, microbiota, well water}, chapternumber = {13605} }
@article{article, year = {2020}, pages = {5}, DOI = {10.1111/cea.13605}, chapter = {13605}, keywords = {atopy, bacterial load, children, drinking water, microbiota, well water}, journal = {Clinical and experimental allergy}, doi = {10.1111/cea.13605}, volume = {50}, issn = {0954-7894}, title = {Association of bacterial load in drinking water and allergic diseases in childhood.}, keyword = {atopy, bacterial load, children, drinking water, microbiota, well water}, chapternumber = {13605} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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