engleski

An Investigation of Argumentation Theory for the Prediction of Survival in Elderly Using Biomarkers

Research on the discovery, classification and validation of biological markers, or biomarkers, have grown extensively in the last decades. Newfound and correctly validated biomarkers have great potential as prognostic and diagnostic indicators, but present a complex relationship with pertinent endpoints such as survival or other diseases manifestations. This research proposes the use of computational argumentation theory as a starting point for the resolution of this problem for cases in which a large amount of data is unavailable. A knowledge-base containing 51 different biomarkers and their association with mortality risks in elderly was provided by a clinician. It was applied for the construction of several argument-based models capable of inferring survival or not. The prediction accuracy and sensitivity of these models were investigated, showing how these are in line with inductive classification using decision trees with limited data.

Biomarkers · Argumentation theory Defeasible reasoning

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