engleski

Embryo-derived teratoma in vitro biological system reveals antitumor and embryotoxic activity of valproate

Lysine acetylation activity of VPA exerts a deleterious effect on the development of the embryo-derived teratoma in vitro that may suggest a novel strategy in the therapy of teratoma tumors in vivo. By analyzing metabolomes from the spent media by FTIR spectroscopy that we associated with the developmental dynamics and bio markers of histone acetylation and apoptosis, we completed the biological system. These findings lead us to the conclusion that the embryo-derived teratoma system, completed by the rapid FTIR spectroscopy, represents arobust, fast dual in vitro screening biological system for the antitumor and embryotoxic/teratogenic agent

histone deacetylase inhibitor ; IRspectroscopy ; teratoma ; valproate

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