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Pregled bibliografske jedinice broj: 1057756

Embryo-derived teratoma in vitro biological system reveals antitumor and embryotoxic activity of valproate


Plazibat, Milvija; Katusic Bojanac, Ana; Himerleich Peric, Marta; Gamulin, Ozren; Rasic, Mario; Radonic, Vedran; Skrabic, Marko; Krajacic, Maria; Krasic, Jure; Sincic, Nino et al.
Embryo-derived teratoma in vitro biological system reveals antitumor and embryotoxic activity of valproate // The FEBS journal, 1 (2019), 101111, 18 doi:10.1111/febs.15248 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1057756 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Embryo-derived teratoma in vitro biological system reveals antitumor and embryotoxic activity of valproate

Autori
Plazibat, Milvija ; Katusic Bojanac, Ana ; Himerleich Peric, Marta ; Gamulin, Ozren ; Rasic, Mario ; Radonic, Vedran ; Skrabic, Marko ; Krajacic, Maria ; Krasic, Jure ; Sincic, Nino ; Juric-Lekic, Gordana ; Balarin, Maja ; Bulic- Jakus, Floriana

Izvornik
The FEBS journal (1742-464X) 1 (2019); 101111, 18

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
histone deacetylase inhibitor ; IRspectroscopy ; teratoma ; valproate

Sažetak
Lysine acetylation activity of VPA exerts a deleterious effect on the development of the embryo-derived teratoma in vitro that may suggest a novel strategy in the therapy of teratoma tumors in vivo. By analyzing metabolomes from the spent media by FTIR spectroscopy that we associated with the developmental dynamics and bio markers of histone acetylation and apoptosis, we completed the biological system. These findings lead us to the conclusion that the embryo-derived teratoma system, completed by the rapid FTIR spectroscopy, represents arobust, fast dual in vitro screening biological system for the antitumor and embryotoxic/teratogenic agent

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Ustanove:
Medicinski fakultet, Zagreb,
Fakultet za dentalnu medicinu i zdravstvo, Osijek

Citiraj ovu publikaciju

Plazibat, Milvija; Katusic Bojanac, Ana; Himerleich Peric, Marta; Gamulin, Ozren; Rasic, Mario; Radonic, Vedran; Skrabic, Marko; Krajacic, Maria; Krasic, Jure; Sincic, Nino et al.
Embryo-derived teratoma in vitro biological system reveals antitumor and embryotoxic activity of valproate // The FEBS journal, 1 (2019), 101111, 18 doi:10.1111/febs.15248 (međunarodna recenzija, članak, znanstveni)
Plazibat, M., Katusic Bojanac, A., Himerleich Peric, M., Gamulin, O., Rasic, M., Radonic, V., Skrabic, M., Krajacic, M., Krasic, J. & Sincic, N. (2019) Embryo-derived teratoma in vitro biological system reveals antitumor and embryotoxic activity of valproate. The FEBS journal, 1, 101111, 18 doi:10.1111/febs.15248.
@article{article, year = {2019}, pages = {18}, DOI = {10.1111/febs.15248}, chapter = {101111}, keywords = {histone deacetylase inhibitor, IRspectroscopy, teratoma, valproate}, journal = {The FEBS journal}, doi = {10.1111/febs.15248}, volume = {1}, issn = {1742-464X}, title = {Embryo-derived teratoma in vitro biological system reveals antitumor and embryotoxic activity of valproate}, keyword = {histone deacetylase inhibitor, IRspectroscopy, teratoma, valproate}, chapternumber = {101111} }
@article{article, year = {2019}, pages = {18}, DOI = {10.1111/febs.15248}, chapter = {101111}, keywords = {histone deacetylase inhibitor, IRspectroscopy, teratoma, valproate}, journal = {The FEBS journal}, doi = {10.1111/febs.15248}, volume = {1}, issn = {1742-464X}, title = {Embryo-derived teratoma in vitro biological system reveals antitumor and embryotoxic activity of valproate}, keyword = {histone deacetylase inhibitor, IRspectroscopy, teratoma, valproate}, chapternumber = {101111} }

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