Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 1057559

Prolonged methylprednisolone premedication prior to obinutuzumab in patients with chronic lymphocytic leukemia


Pejsa, Vlatko; Lucijanic, Marko; Vrkljan Vuk, Anamarija; Stoos-Veic, Tajana; Jaksic, Ozren; Jonjic, Željko; Pirsic, Mario; Prka, Željko; Ivic, Marija; Fazlic Dzankic, Amina; Mitrovic , Zdravko
Prolonged methylprednisolone premedication prior to obinutuzumab in patients with chronic lymphocytic leukemia // Leukemia & lymphoma, 61 (2020), 4; 934-939 doi:10.1080/10428194.2019.1702182 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1057559 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Prolonged methylprednisolone premedication prior to obinutuzumab in patients with chronic lymphocytic leukemia

Autori
Pejsa, Vlatko ; Lucijanic, Marko ; Vrkljan Vuk, Anamarija ; Stoos-Veic, Tajana ; Jaksic, Ozren ; Jonjic, Željko ; Pirsic, Mario ; Prka, Željko ; Ivic, Marija ; Fazlic Dzankic, Amina ; Mitrovic , Zdravko

Izvornik
Leukemia & lymphoma (1042-8194) 61 (2020), 4; 934-939

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Chronic lymphocytic leukemia, obinutuzumab, infusion related reactions, premedication, corticosteroids, methylprednisolone

Sažetak
First obinutuzumab application is associated with infusion related reactions (IRRs) that may discourage further continuation of the drug. During our clinical practice we have observed that chronic lymphocytic leukemia (CLL) patients with autoimmune hemolytic anemia (AIHA) prolongedly receiving corticosteroids do not develop obinutuzumab IRRs. Therefore, we decided to apply prolonged corticosteroid premedication with methylprednisolone in dose 1–1.5 mg/kg for ≥7 days to all further obinutuzumab candidates. Here we present non-randomized comparison of 28 consecutive previously untreated CLL patients receiving prolonged corticosteroid premedication (15 patients) or standard premedication (13 patients) prior to the first obinutuzumab infusion. Prolonged corticosteroid premedication resulted in significant reduction of all-grade (20% vs 61.5% ; p = .025) and grade III (0% vs 23.1% ; p = .049) obinutuzumab IRRs. Prolonged corticosteroid premedication did not significantly affect occurrence of infective complications. Patients with CLL and AIHA receiving obinutuzumab showed continuous and stable increase in hemoglobin levels concomitantly with decrease in parameters of hemolysis.

Izvorni jezik
Engleski



POVEZANOST RADA


Ustanove:
Klinička bolnica "Dubrava",
Medicinski fakultet, Osijek

doi

Citiraj ovu publikaciju

Pejsa, Vlatko; Lucijanic, Marko; Vrkljan Vuk, Anamarija; Stoos-Veic, Tajana; Jaksic, Ozren; Jonjic, Željko; Pirsic, Mario; Prka, Željko; Ivic, Marija; Fazlic Dzankic, Amina; Mitrovic , Zdravko
Prolonged methylprednisolone premedication prior to obinutuzumab in patients with chronic lymphocytic leukemia // Leukemia & lymphoma, 61 (2020), 4; 934-939 doi:10.1080/10428194.2019.1702182 (međunarodna recenzija, članak, znanstveni)
Pejsa, V., Lucijanic, M., Vrkljan Vuk, A., Stoos-Veic, T., Jaksic, O., Jonjic, Ž., Pirsic, M., Prka, Ž., Ivic, M., Fazlic Dzankic, A. & Mitrovic , Z. (2020) Prolonged methylprednisolone premedication prior to obinutuzumab in patients with chronic lymphocytic leukemia. Leukemia & lymphoma, 61 (4), 934-939 doi:10.1080/10428194.2019.1702182.
@article{article, year = {2020}, pages = {934-939}, DOI = {10.1080/10428194.2019.1702182}, keywords = {Chronic lymphocytic leukemia, obinutuzumab, infusion related reactions, premedication, corticosteroids, methylprednisolone}, journal = {Leukemia and lymphoma}, doi = {10.1080/10428194.2019.1702182}, volume = {61}, number = {4}, issn = {1042-8194}, title = {Prolonged methylprednisolone premedication prior to obinutuzumab in patients with chronic lymphocytic leukemia}, keyword = {Chronic lymphocytic leukemia, obinutuzumab, infusion related reactions, premedication, corticosteroids, methylprednisolone} }
@article{article, year = {2020}, pages = {934-939}, DOI = {10.1080/10428194.2019.1702182}, keywords = {Chronic lymphocytic leukemia, obinutuzumab, infusion related reactions, premedication, corticosteroids, methylprednisolone}, journal = {Leukemia and lymphoma}, doi = {10.1080/10428194.2019.1702182}, volume = {61}, number = {4}, issn = {1042-8194}, title = {Prolonged methylprednisolone premedication prior to obinutuzumab in patients with chronic lymphocytic leukemia}, keyword = {Chronic lymphocytic leukemia, obinutuzumab, infusion related reactions, premedication, corticosteroids, methylprednisolone} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Citati





    Contrast
    Increase Font
    Decrease Font
    Dyslexic Font