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Pregled bibliografske jedinice broj: 1057471

Validation of a clinical score in predicting pancreatic fistula after pancreaticoduodenectomy


Kopljar, Mario; Čoklo, Miran; Krstačić, Antonija; Krstačić, Goran; Jeleč, Vjekoslav; Zovak, Mario; Pavić, Roman; Kondža, Goran
Validation of a clinical score in predicting pancreatic fistula after pancreaticoduodenectomy // Acta chirurgica Belgica (Ed. bilingue) (2019) (znanstveni, prihvaćen)


Naslov
Validation of a clinical score in predicting pancreatic fistula after pancreaticoduodenectomy

Autori
Kopljar, Mario ; Čoklo, Miran ; Krstačić, Antonija ; Krstačić, Goran ; Jeleč, Vjekoslav ; Zovak, Mario ; Pavić, Roman ; Kondža, Goran

Vrsta, podvrsta
Radovi u časopisima, znanstveni

Izvornik
Acta chirurgica Belgica (Ed. bilingue) (2019)

Status rada
Prihvaćen

Ključne riječi
Pancreaticoduodenectomy ; pancreatic fistula ; clinical score ; risk assessment ; decision support techniques

Sažetak
ABSTRACT Background: Postoperative pancreatic fistula (POPF) is one of the most severe complications after cephalic pancreaticoduodenectomy, with mortality as high as 30%. Risk scores may help predict the risk of POPF. Multiple external validations substantially improve generalized clinical acceptability of a scoring system. Aim: The aim of this study was to externally validate previously described fistula risk score in the prediction of clinically relevant POPF. Methods: All patients who underwent pancreaticoduodenectomy for any indication during a 5-year period were prospectively analyzed. A total of 132 patients were analyzed. Results: Of the 132 patients, 44 (33.3%) developed pancreatic fistula, including 12.9% bio- chemical leaks, 7.6% grade B fistula, and 12.9% grade C fistula. Cut-off point of 4.5 was determined to best separate patients who developed clinically relevant POPF with area under curve of 78% (p 1⁄4 .00003). Sensitivity and specificity for the prediction of clinically relevant POPF with the cut-off value of 4.5 was 70.4 and 74.3%, respectively. Positive predict- ive value with cut-off value 4.5 was 57.8%, and negative predictive value was 83.4%. Conclusion: Fistula risk score identified low risk patients with false negative rate of 16.6%. Further external validation studies on large cohorts of patients and with wide case-mix may enable additional refinements of the score model.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove
Klinički bolnički centar Osijek,
KBC "Sestre Milosrdnice",
Klinika za traumatologiju,
Institut za antropologiju,
Klinička bolnica "Dubrava",
Zdravstveno veleučilište, Zagreb,
Medicinski fakultet, Osijek,
Fakultet za dentalnu medicinu i zdravstvo, Osijek

Citiraj ovu publikaciju

Kopljar, Mario; Čoklo, Miran; Krstačić, Antonija; Krstačić, Goran; Jeleč, Vjekoslav; Zovak, Mario; Pavić, Roman; Kondža, Goran
Validation of a clinical score in predicting pancreatic fistula after pancreaticoduodenectomy // Acta chirurgica Belgica (Ed. bilingue) (2019) (znanstveni, prihvaćen)
Kopljar, M., Čoklo, M., Krstačić, A., Krstačić, G., Jeleč, V., Zovak, M., Pavić, R. & Kondža, G. (2019) Validation of a clinical score in predicting pancreatic fistula after pancreaticoduodenectomy. Prihvaćen za objavljivanje u Acta chirurgica Belgica (Ed. bilingue). [Preprint].
@unknown{unknown, year = {2019}, keywords = {Pancreaticoduodenectomy, pancreatic fistula, clinical score, risk assessment, decision support techniques}, journal = {Acta chirurgica Belgica (Ed. bilingue)}, title = {Validation of a clinical score in predicting pancreatic fistula after pancreaticoduodenectomy}, keyword = {Pancreaticoduodenectomy, pancreatic fistula, clinical score, risk assessment, decision support techniques} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE