engleski

White wine has beneficial effects on expression of inflammatory markers/mediators following myocardial infarction in rats

The aim of our study was to investigate the effect of white wine consumption on the expression of inflammatory markers/mediators (MMP-2, MMP-9, NF-ĸB and TGF-β) in the myocardial tissue following experimentally induced permanent myocardial ischemia. Male Sprague-Dawley rats (n=10) were randomized into two groups: drinking a combination of wine (Graševina) and water and those drinking water only for 28 days. After performing the coronary ligation, animals were left to survive for 24 hours and then sacrificed. Three representative zones for each group of animals: infarct/ischemic, peri-infarct/border zone and control/non-ischemic zones were analysed for the expression of immunoreactivity for the above markers. The threshold area % of signal density for each marker was measured and For MMP-9, a significantly smaller expression was found in all three zones of wine drinking animals group (p<0.001). There was no difference in MMP-2 immunoreactivity between two groups, except in the peri-infarct zones, where again a significant decrease of the signal (p<0.001) was found. A significant decrease of NF-ĸB signal was also found in the peri- infarct zone of wine-drinking animals when compared with water-drinking group (p<0.001) while no differences between experimental groups was observed for TGF-β. White wine consumption significantly decreases expression of inflammatory markers in the peri-infarct zone suggesting not only its preconditioning potential but also strong (inflammation- related) modulatory effect, which is for MMP expression similar to the effect post-ischemic reperfusion.

White Wine, Inflammatory Markers, Myocardial Infarction

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