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Pregled bibliografske jedinice broj: 1056785

Substituted Adamantylphthalimides: Synthesis, Antiviral and Antiproliferative Activity


Mandić, Leo; Benčić, Patricia; Mlinarić-Majerski, Kata; Liekens, Sandra; Snoeck, Robert; Andrei, Graciela; Kralj, Marijeta; Basarić, Nikola
Substituted Adamantylphthalimides: Synthesis, Antiviral and Antiproliferative Activity // Archiv der Pharmazie, 353 (2020), 6; 2000024, 10 doi:10.1002/ardp.202000024 (međunarodna recenzija, članak, znanstveni)


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Naslov
Substituted Adamantylphthalimides: Synthesis, Antiviral and Antiproliferative Activity

Autori
Mandić, Leo ; Benčić, Patricia ; Mlinarić-Majerski, Kata ; Liekens, Sandra ; Snoeck, Robert ; Andrei, Graciela ; Kralj, Marijeta ; Basarić, Nikola

Izvornik
Archiv der Pharmazie (0365-6233) 353 (2020), 6; 2000024, 10

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Adamantane ; Antiproliferative activity ; Antiviral activity ; Phthalimide

Sažetak
Three groups of adamantylphthalimides, bearing different substituents at the phthalimide moiety, N-(4′-R2)phthalimidoadamantanes, 1-7, 3-[N-(4′-R2)phthalimido]-1-adamantanols, 8-10 and 3-[N-(4′-R2)phthalimido]adamantane-1-carboxylic acids 11-15, were synthesized and screened against tumor cells and viruses. The most potent compounds are not substituted at the adamantane and bear OH or NH2 substituent at the phthalimide (compounds 3 and 5). The antiproliferative activity of 3 and 5 is in micromolar range, much higher than the one of thalidomide. Minor antiviral activity against cytomegalovirus and varicella-zoster virus was found for 3 and 5 but these compounds lacked selectivity. The results presented are important for the rational design of next generation of compounds with anticancer and antiviral activity.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)



POVEZANOST RADA


Projekt / tema
HRZZ-IP-2013-11-5660 - Mulitidisciplinarni pristup otkriću lijekova s ciljanim djelovanjem na matične stanice tumora – uloga transporta kalija (Marijeta Kralj, )
HRZZ-IP-2014-09-6312 - Supramolekulska kontrola fotokemijskih reakcija eliminacije (Nikola Basarić, )

Ustanove
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Marijeta Kralj (autor)

Avatar Url Nikola Basarić (autor)

Avatar Url Kata Majerski (autor)

Avatar Url Leo Mandić (autor)

Citiraj ovu publikaciju

Mandić, Leo; Benčić, Patricia; Mlinarić-Majerski, Kata; Liekens, Sandra; Snoeck, Robert; Andrei, Graciela; Kralj, Marijeta; Basarić, Nikola
Substituted Adamantylphthalimides: Synthesis, Antiviral and Antiproliferative Activity // Archiv der Pharmazie, 353 (2020), 6; 2000024, 10 doi:10.1002/ardp.202000024 (međunarodna recenzija, članak, znanstveni)
Mandić, L., Benčić, P., Mlinarić-Majerski, K., Liekens, S., Snoeck, R., Andrei, G., Kralj, M. & Basarić, N. (2020) Substituted Adamantylphthalimides: Synthesis, Antiviral and Antiproliferative Activity. Archiv der Pharmazie, 353 (6), 2000024, 10 doi:10.1002/ardp.202000024.
@article{article, year = {2020}, pages = {10}, DOI = {10.1002/ardp.202000024}, chapter = {2000024}, keywords = {Adamantane, Antiproliferative activity, Antiviral activity, Phthalimide}, journal = {Archiv der Pharmazie}, doi = {10.1002/ardp.202000024}, volume = {353}, number = {6}, issn = {0365-6233}, title = {Substituted Adamantylphthalimides: Synthesis, Antiviral and Antiproliferative Activity}, keyword = {Adamantane, Antiproliferative activity, Antiviral activity, Phthalimide}, chapternumber = {2000024} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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