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Pregled bibliografske jedinice broj: 1056753

Evaluation of oxidative stress responses and primary DNA damage in blood and brain of rats exposed to low levels of tembotrione


Tariba Lovaković, Blanka; Kašuba, Vilena; Katić, Anja; Kopjar, Nevenka; Marjanović Čermak, Ana Marija; Micek, Vedran; Milić, Mirta; Pavičić, Ivan; Pizent, Alica; Žunec, Suzana; Želježić, Davor
Evaluation of oxidative stress responses and primary DNA damage in blood and brain of rats exposed to low levels of tembotrione // Chemosphere, 253 (2020), 126643, 10 doi:j.chemosphere.2020.126643 (međunarodna recenzija, članak, znanstveni)


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Naslov
Evaluation of oxidative stress responses and primary DNA damage in blood and brain of rats exposed to low levels of tembotrione

Autori
Tariba Lovaković, Blanka ; Kašuba, Vilena ; Katić, Anja ; Kopjar, Nevenka ; Marjanović Čermak, Ana Marija ; Micek, Vedran ; Milić, Mirta ; Pavičić, Ivan ; Pizent, Alica ; Žunec, Suzana ; Želježić, Davor

Izvornik
Chemosphere (0045-6535) 253 (2020); 126643, 10

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Tembotrione ; Comet assay ; Antioxidant enzymes ; Lipid peroxidation

Sažetak
Tembotrione is a rather novel pesticide, usually used for post-emergence weed control. Even though its use is rapidly growing, it is not followed by an adequate flow of scientific evidence regarding its toxicity towards non-target organisms. We evaluated the potential of low doses of tembotrione to induce oxidative stress and cytogenetic damage in blood and brain cells of adult male Wistar rats. Parameters of lipid peroxidation, glutathione levels, activities of antioxidant enzymes and primary DNA damage were assessed following 28-day repeated oral exposure to doses comparable with the currently proposed health-based reference values. The results of the alkaline comet assay showed that such low doses of tembotrione have the potency to inflict primary DNA damage in both peripheral blood leukocytes and brain of treated rats, even with only slight changes in the oxidative biomarker levels. The DNA damage in blood and brain cells of Wistar rats significantly increased at all applied doses, suggesting that tembotrione genotoxicity is mainly a result of direct interaction with DNA while the induction of oxidative stress responses contributes to DNA instability in a lesser extent. The findings of the present study call for further research using other sensitive biomarkers of effect and different exposure scenarios.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
HRZZ-IP-2013-11-8366 - Organska zagađivala u okolišu - markeri i biomarkeri toksičnosti (OPENTOX) (Želježić, Davor, HRZZ - 2013-11) ( POIROT)

Ustanove:
Institut za medicinska istraživanja i medicinu rada, Zagreb

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com

Citiraj ovu publikaciju:

Tariba Lovaković, Blanka; Kašuba, Vilena; Katić, Anja; Kopjar, Nevenka; Marjanović Čermak, Ana Marija; Micek, Vedran; Milić, Mirta; Pavičić, Ivan; Pizent, Alica; Žunec, Suzana; Želježić, Davor
Evaluation of oxidative stress responses and primary DNA damage in blood and brain of rats exposed to low levels of tembotrione // Chemosphere, 253 (2020), 126643, 10 doi:j.chemosphere.2020.126643 (međunarodna recenzija, članak, znanstveni)
Tariba Lovaković, B., Kašuba, V., Katić, A., Kopjar, N., Marjanović Čermak, A., Micek, V., Milić, M., Pavičić, I., Pizent, A., Žunec, S. & Želježić, D. (2020) Evaluation of oxidative stress responses and primary DNA damage in blood and brain of rats exposed to low levels of tembotrione. Chemosphere, 253, 126643, 10 doi:j.chemosphere.2020.126643.
@article{article, author = {Tariba Lovakovi\'{c}, Blanka and Ka\v{s}uba, Vilena and Kati\'{c}, Anja and Kopjar, Nevenka and Marjanovi\'{c} \v{C}ermak, Ana Marija and Micek, Vedran and Mili\'{c}, Mirta and Pavi\v{c}i\'{c}, Ivan and Pizent, Alica and \v{Z}unec, Suzana and \v{Z}elje\v{z}i\'{c}, Davor}, year = {2020}, pages = {10}, DOI = {j.chemosphere.2020.126643}, chapter = {126643}, keywords = {Tembotrione, Comet assay, Antioxidant enzymes, Lipid peroxidation}, journal = {Chemosphere}, doi = {j.chemosphere.2020.126643}, volume = {253}, issn = {0045-6535}, title = {Evaluation of oxidative stress responses and primary DNA damage in blood and brain of rats exposed to low levels of tembotrione}, keyword = {Tembotrione, Comet assay, Antioxidant enzymes, Lipid peroxidation}, chapternumber = {126643} }
@article{article, author = {Tariba Lovakovi\'{c}, Blanka and Ka\v{s}uba, Vilena and Kati\'{c}, Anja and Kopjar, Nevenka and Marjanovi\'{c} \v{C}ermak, Ana Marija and Micek, Vedran and Mili\'{c}, Mirta and Pavi\v{c}i\'{c}, Ivan and Pizent, Alica and \v{Z}unec, Suzana and \v{Z}elje\v{z}i\'{c}, Davor}, year = {2020}, pages = {10}, DOI = {j.chemosphere.2020.126643}, chapter = {126643}, keywords = {Tembotrione, Comet assay, Antioxidant enzymes, Lipid peroxidation}, journal = {Chemosphere}, doi = {j.chemosphere.2020.126643}, volume = {253}, issn = {0045-6535}, title = {Evaluation of oxidative stress responses and primary DNA damage in blood and brain of rats exposed to low levels of tembotrione}, keyword = {Tembotrione, Comet assay, Antioxidant enzymes, Lipid peroxidation}, chapternumber = {126643} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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