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Pregled bibliografske jedinice broj: 1055028

Differential DNA methylation of vocal and facial anatomy genes in modern humans


Gokhman, David; Nissim-Rafinia, Malka; Agranat-Tamir, Lily; Housman, Genevieve; García-Pérez, Raquel; Lizano, Esther; Cheronet, Olivia; Mallick, Swapan; Nieves-Colón, Maria A.; Li, Heng et al.
Differential DNA methylation of vocal and facial anatomy genes in modern humans // Nature Communications, 11 (2020), 1189, 21 doi:10.1038/s41467-020-15020-6 (međunarodna recenzija, članak, znanstveni)


Naslov
Differential DNA methylation of vocal and facial anatomy genes in modern humans

Autori
Gokhman, David ; Nissim-Rafinia, Malka ; Agranat-Tamir, Lily ; Housman, Genevieve ; García-Pérez, Raquel ; Lizano, Esther ; Cheronet, Olivia ; Mallick, Swapan ; Nieves-Colón, Maria A. ; Li, Heng ; Alpaslan-Roodenberg, Songül ; Novak, Mario ; Gu, Hongcang ; Josinski, Jason M. ; Ferrando-Bernal, Manuel ; Gelabert, Pere ; Lipende, Iddi ; Mjungu, Deus ; Kondova, Ivanela ; Bontrop, Ronald ; Kullmer, Ottmar ; Weber, Gerhard ; Shahar, Tal ; Dvir-Ginzberg, Mona ; Faerman, Marina ; Quillen, Ellen E. ; Meissner, Alexander ; Lahav, Yonatan ; Kandel, Leonid ; Liebergall, Meir ; Prada, María E. ; Vidal, Julio M. ; Gronostajski, Richard M. ; Stone, Anne C. ; Yakir, Benjamin ; Lalueza-Fox, Carles ; Pinhasi, Ron ; Reich, David ; Marques-Bonet, Tomas ; Meshorer, Eran ; Carmel, Liran

Izvornik
Nature Communications (2041-1723) 11 (2020); 1189, 21

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Methylation ; anatomy ; vocal ; facial ; modern humans

Sažetak
Changes in potential regulatory elements are thought to be key drivers of phenotypic divergence. However, identifying changes to regulatory elements that underlie human-specific traits has proven very challenging. Here, we use 63 reconstructed and experimentally measured DNA methylation maps of ancient and present-day humans, as well as of six chimpanzees, to detect differentially methylated regions that likely emerged in modern humans after the split from Neanderthals and Denisovans. We show that genes associated with face and vocal tract anatomy went through particularly extensive methylation changes. Specifically, we identify widespread hypermethylation in a network of face- and voice-associated genes (SOX9, ACAN, COL2A1, NFIX and XYLT1). We propose that these repression patterns appeared after the split from Neanderthals and Denisovans, and that they might have played a key role in shaping the modern human face and vocal tract.

Izvorni jezik
Engleski

Znanstvena područja
Arheologija



POVEZANOST RADA


Ustanove
Institut za antropologiju

Profili:

Avatar Url Mario Novak (autor)

Citiraj ovu publikaciju

Gokhman, David; Nissim-Rafinia, Malka; Agranat-Tamir, Lily; Housman, Genevieve; García-Pérez, Raquel; Lizano, Esther; Cheronet, Olivia; Mallick, Swapan; Nieves-Colón, Maria A.; Li, Heng et al.
Differential DNA methylation of vocal and facial anatomy genes in modern humans // Nature Communications, 11 (2020), 1189, 21 doi:10.1038/s41467-020-15020-6 (međunarodna recenzija, članak, znanstveni)
Gokhman, D., Nissim-Rafinia, M., Agranat-Tamir, L., Housman, G., García-Pérez, R., Lizano, E., Cheronet, O., Mallick, S., Nieves-Colón, M. & Li, H. (2020) Differential DNA methylation of vocal and facial anatomy genes in modern humans. Nature Communications, 11, 1189, 21 doi:10.1038/s41467-020-15020-6.
@article{article, year = {2020}, pages = {21}, DOI = {10.1038/s41467-020-15020-6}, chapter = {1189}, keywords = {Methylation, anatomy, vocal, facial, modern humans}, journal = {Nature Communications}, doi = {10.1038/s41467-020-15020-6}, volume = {11}, issn = {2041-1723}, title = {Differential DNA methylation of vocal and facial anatomy genes in modern humans}, keyword = {Methylation, anatomy, vocal, facial, modern humans}, chapternumber = {1189} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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