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Pregled bibliografske jedinice broj: 1054772

Luteolin ameliorates experimental colitis in mice through ERK-mediated suppression of inflammation, apoptosis and autophagy


Vukelić, Iva; Detel, Dijana; Batičić, Lara; Potočnjak, Iva; Domitrović, Robert
Luteolin ameliorates experimental colitis in mice through ERK-mediated suppression of inflammation, apoptosis and autophagy // Food and chemical toxicology, 145 (2020), 111680, 14 doi:10.1016/j.fct.2020.111680 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1054772 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Luteolin ameliorates experimental colitis in mice through ERK-mediated suppression of inflammation, apoptosis and autophagy

Autori
Vukelić, Iva ; Detel, Dijana ; Batičić, Lara ; Potočnjak, Iva ; Domitrović, Robert

Izvornik
Food and chemical toxicology (0944-7113) 145 (2020); 111680, 14

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Apoptosis ; autophagy ; extracellular signal-regulated kinase 1/2 ; inflammation ; luteolin ; ulcerative colitis.

Sažetak
Background: Ulcerative colitis (UC) is a chronic inflammatory disease with increasing incidence and prevalence worldwide. Currently used treatments of UC are unsatisfactory while natural biactive compounds are considered to be emerging therapeutic agents. Luteolin (Lut) is a natural compound with beneficial effects in a variety of diseases, however, its effect in UC has been poorly studied. Purpose: This study attempted to clarify molecular mechanisms behind the biological activity of Lut in the treatment of UC, with the emphasis on the extracellular signal-regulated kinase (ERK) signaling pathway. Study design: The effect of Lut was investigated in a posttreatment and cotreatment of dextran sulfate sodium (DSS)- induced experimental colitis in mice. In addition, the role of ERK1/2 in the mechanism of action of Lut in experimental colitis was investigated using ERK1/2 inhibitor. Methods: Clinical symptoms (disease activity index) and histopathological changes of the colon were evaluated during disease development. The expression of mitogen-activated protein kinase (MAPKs), inflammatory markers and apoptotic and autophagic proteins were determined by western blot. Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) p65 expression and cellular localization were analyzed by immunohistochemistry. Results: Lut administration attenuated symptoms of DSS- induced colitis in mice, ameliorated colon tissue damage and reduced inflammation, apoptosis and autophagy. The effect was more pronounced if Lut was administrated at the time of colitis induction (cotreatment). The administration of ERK1/2 inhibitor exacerbated DSS-induced colitis symptoms and prevented the protective effects of Lut. Conclusion: This study provides new mechanistic details underlying the anti-inflammatory, anti- apoptotic and anti-autophagic effects of Lut through the activation of the ERK signaling pathway. This suggested that Lut can be used as a novel therapeutic candidate in the treatment of UC or could be used as a supplement to existing therapy.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Farmacija



POVEZANOST RADA


Ustanove:
Medicinski fakultet, Rijeka

Profili:

Avatar Url Lara Batičić (autor)

Avatar Url Dijana Detel (autor)

Avatar Url Iva Potočnjak (autor)

Avatar Url Iva Vukelić (autor)

Avatar Url Robert Domitrović (autor)

Citiraj ovu publikaciju

Vukelić, Iva; Detel, Dijana; Batičić, Lara; Potočnjak, Iva; Domitrović, Robert
Luteolin ameliorates experimental colitis in mice through ERK-mediated suppression of inflammation, apoptosis and autophagy // Food and chemical toxicology, 145 (2020), 111680, 14 doi:10.1016/j.fct.2020.111680 (međunarodna recenzija, članak, znanstveni)
Vukelić, I., Detel, D., Batičić, L., Potočnjak, I. & Domitrović, R. (2020) Luteolin ameliorates experimental colitis in mice through ERK-mediated suppression of inflammation, apoptosis and autophagy. Food and chemical toxicology, 145, 111680, 14 doi:10.1016/j.fct.2020.111680.
@article{article, year = {2020}, pages = {14}, DOI = {10.1016/j.fct.2020.111680}, chapter = {111680}, keywords = {Apoptosis, autophagy, extracellular signal-regulated kinase 1/2, inflammation, luteolin, ulcerative colitis.}, journal = {Food and chemical toxicology}, doi = {10.1016/j.fct.2020.111680}, volume = {145}, issn = {0944-7113}, title = {Luteolin ameliorates experimental colitis in mice through ERK-mediated suppression of inflammation, apoptosis and autophagy}, keyword = {Apoptosis, autophagy, extracellular signal-regulated kinase 1/2, inflammation, luteolin, ulcerative colitis.}, chapternumber = {111680} }
@article{article, year = {2020}, pages = {14}, DOI = {10.1016/j.fct.2020.111680}, chapter = {111680}, keywords = {Apoptosis, autophagy, extracellular signal-regulated kinase 1/2, inflammation, luteolin, ulcerative colitis.}, journal = {Food and chemical toxicology}, doi = {10.1016/j.fct.2020.111680}, volume = {145}, issn = {0944-7113}, title = {Luteolin ameliorates experimental colitis in mice through ERK-mediated suppression of inflammation, apoptosis and autophagy}, keyword = {Apoptosis, autophagy, extracellular signal-regulated kinase 1/2, inflammation, luteolin, ulcerative colitis.}, chapternumber = {111680} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • Social Science Citation Index (SSCI)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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