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Bis(triazolylpyrene)-derived Pseudopeptides: Synthesis, Fluorescence Properties and In Situ Formation of Nanoaggregates in Cells (CROSBI ID 689071)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija

Belovari, Mateja ; Ban Željka ; Džolić, Zoran Bis(triazolylpyrene)-derived Pseudopeptides: Synthesis, Fluorescence Properties and In Situ Formation of Nanoaggregates in Cells // Book of abstracts. 2019. str. 262-262

Podaci o odgovornosti

Belovari, Mateja ; Ban Željka ; Džolić, Zoran

engleski

Bis(triazolylpyrene)-derived Pseudopeptides: Synthesis, Fluorescence Properties and In Situ Formation of Nanoaggregates in Cells

Self-assembled peptide nanostructures are very promising biomaterial with huge potential in several biomedical applications. Pyrene is one of the most useful fluorogenic unit because of its high detection sensitivity. Formation of the self assembled complex results in a remarkable change in the fluorescence emission intensities of the pyrene excimer and monomer. Due to their many interesting fluorescence properties, such as long lifetime, high quantum yield, and the possibility to form excimers, pyrene and its derivatives are of considerable interest for the development of sensors and diagnostic tools. In aim of design of fluorescent organic nanoparticles, novel products containing pyrene chromophore linked via a triazole ring to an amino acid derivatives were synthesised using Cu-catalized “click” reaction. We report the synthesis of novel bis(triazolylpyrene)-derived pseudopeptides, their photophysical properties, self-assembly in DMSO/H2O as well as confocal fluorescence microscopy studies. Their bioactivity and cellular uptake will be tested on a panel of human tumor cell lines.

; yrene, Self-assembly ; Fluorescent Organic Nanoparticles ; Nanoaggregates in Cells

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Podaci o prilogu

262-262.

2019.

objavljeno

Podaci o matičnoj publikaciji

Book of abstracts

Podaci o skupu

EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry (EFMC-ASMC'19)

poster

01.09.2019-05.09.2019

Atena, Grčka

Povezanost rada

Kemija