Bis(triazolylpyrene)-derived Pseudopeptides: Synthesis, Fluorescence Properties and In Situ Formation of Nanoaggregates in Cells (CROSBI ID 689071)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Belovari, Mateja ; Ban Željka ; Džolić, Zoran
engleski
Bis(triazolylpyrene)-derived Pseudopeptides: Synthesis, Fluorescence Properties and In Situ Formation of Nanoaggregates in Cells
Self-assembled peptide nanostructures are very promising biomaterial with huge potential in several biomedical applications. Pyrene is one of the most useful fluorogenic unit because of its high detection sensitivity. Formation of the self assembled complex results in a remarkable change in the fluorescence emission intensities of the pyrene excimer and monomer. Due to their many interesting fluorescence properties, such as long lifetime, high quantum yield, and the possibility to form excimers, pyrene and its derivatives are of considerable interest for the development of sensors and diagnostic tools. In aim of design of fluorescent organic nanoparticles, novel products containing pyrene chromophore linked via a triazole ring to an amino acid derivatives were synthesised using Cu-catalized “click” reaction. We report the synthesis of novel bis(triazolylpyrene)-derived pseudopeptides, their photophysical properties, self-assembly in DMSO/H2O as well as confocal fluorescence microscopy studies. Their bioactivity and cellular uptake will be tested on a panel of human tumor cell lines.
; yrene, Self-assembly ; Fluorescent Organic Nanoparticles ; Nanoaggregates in Cells
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Podaci o prilogu
262-262.
2019.
objavljeno
Podaci o matičnoj publikaciji
Book of abstracts
Podaci o skupu
EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry (EFMC-ASMC'19)
poster
01.09.2019-05.09.2019
Atena, Grčka