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Pregled bibliografske jedinice broj: 1054718

Oleanolic acid attenuates cisplatin-induced nephrotoxicity in mice and chemosensitizes human cervical cancer cells to cisplatin cytotoxicity


Potočnjak, Iva; Šimić, Lidija; Vukelić, Iva; Domitrović, Robert
Oleanolic acid attenuates cisplatin-induced nephrotoxicity in mice and chemosensitizes human cervical cancer cells to cisplatin cytotoxicity // HDBMB2019 Crossroads in Life Sciences Book of Abstracts / Katalinić, Maja ; Dulić, Morana ; Stuparević Igor (ur.).
Zagreb, 2019. str. 107-107 (poster, međunarodna recenzija, sažetak, ostalo)


CROSBI ID: 1054718 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Oleanolic acid attenuates cisplatin-induced nephrotoxicity in mice and chemosensitizes human cervical cancer cells to cisplatin cytotoxicity

Autori
Potočnjak, Iva ; Šimić, Lidija ; Vukelić, Iva ; Domitrović, Robert

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
HDBMB2019 Crossroads in Life Sciences Book of Abstracts / Katalinić, Maja ; Dulić, Morana ; Stuparević Igor - Zagreb, 2019, 107-107

ISBN
978-953-95551-7-5

Skup
HDBMB Crossroads in Life Sciences

Mjesto i datum
Lovran, Hrvatska, 25-28. 9. 2019

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
oleanolic acid ; cisplatin ; kidney ; cervical cancer cells ; apoptosis ; autophagy

Sažetak
Oleanolic acid (OA) is a natural triterpenoid that possesses numerous beneficial health effects such as antioxidant, anti-inflammatory and anti-apoptotic activities. In this study, we investigated the therapeutic effect of OA (10 and 40 mg/kg) on cisplatin (CP)-induced (13 mg/kg) nephrotoxicity. Treatment with OA 40 mg/kg once daily for 2 days, 48 h after CP- intoxication, ameliorated the increased serum markers and histological features of kidney injury. CP administration increased renal expression of antioxidant and anti-inflammatory markers, which was reduced by OA. The increase in proapoptotic caspase-3 and -9 activations, with concomitant increase in poly (ADP-ribose) polymerase (PARP) cleavage, were dose- dependently inhibited by OA. Treatment with OA also ameliorated microtubule-associated protein 1A/1B-light chain 3B (LC3B)-II and autophagy- related protein (Atg) 5 expression induced by CP. The suppression of CP-induced oxidative stress, apoptosis, autophagy and inflammatory response by OA coincided with the inhibition of extracellular-regulated kinase (ERK) 1/2, signal transducer and activator of transcription (STAT) 3 and nuclear factor-kappa B (NF-κB). Interestingly, OA increased CP cytotoxicity in HeLa cervical cancer cells by inducing cytotoxic autophagy. The chemosensitization of HeLa cells to CP suggests a potential beneficial effect of OA in cervical cancer patients due to reduced CP dosage requirements, which requires further investigation.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Farmacija



POVEZANOST RADA


Ustanove:
Medicinski fakultet, Rijeka

Profili:

Avatar Url Iva Potočnjak (autor)

Avatar Url Iva Vukelić (autor)

Avatar Url Robert Domitrović (autor)


Citiraj ovu publikaciju

Potočnjak, Iva; Šimić, Lidija; Vukelić, Iva; Domitrović, Robert
Oleanolic acid attenuates cisplatin-induced nephrotoxicity in mice and chemosensitizes human cervical cancer cells to cisplatin cytotoxicity // HDBMB2019 Crossroads in Life Sciences Book of Abstracts / Katalinić, Maja ; Dulić, Morana ; Stuparević Igor (ur.).
Zagreb, 2019. str. 107-107 (poster, međunarodna recenzija, sažetak, ostalo)
Potočnjak, I., Šimić, L., Vukelić, I. & Domitrović, R. (2019) Oleanolic acid attenuates cisplatin-induced nephrotoxicity in mice and chemosensitizes human cervical cancer cells to cisplatin cytotoxicity. U: Katalinić, M., Dulić, M. & Stuparević Igor (ur.)HDBMB2019 Crossroads in Life Sciences Book of Abstracts.
@article{article, year = {2019}, pages = {107-107}, keywords = {oleanolic acid, cisplatin, kidney, cervical cancer cells, apoptosis, autophagy}, isbn = {978-953-95551-7-5}, title = {Oleanolic acid attenuates cisplatin-induced nephrotoxicity in mice and chemosensitizes human cervical cancer cells to cisplatin cytotoxicity}, keyword = {oleanolic acid, cisplatin, kidney, cervical cancer cells, apoptosis, autophagy}, publisherplace = {Lovran, Hrvatska} }
@article{article, year = {2019}, pages = {107-107}, keywords = {oleanolic acid, cisplatin, kidney, cervical cancer cells, apoptosis, autophagy}, isbn = {978-953-95551-7-5}, title = {Oleanolic acid attenuates cisplatin-induced nephrotoxicity in mice and chemosensitizes human cervical cancer cells to cisplatin cytotoxicity}, keyword = {oleanolic acid, cisplatin, kidney, cervical cancer cells, apoptosis, autophagy}, publisherplace = {Lovran, Hrvatska} }




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