engleski

Species Distribution and Antifungal Susceptibility of Candida isolated from blood cultures

Aim: This study was performed to investigate the species distribution of Candida isolated from blood cultures, and to evaluate antifungal susceptibility during six-year period at a tertiary-care hospital. Material and Methods: This is a retrospective review of all the Candida isolates recovered from blood of patients hospitalized in the Clinical Hospital Centre Rijeka, in the period from 2013 to 2018. Relevant data were obtained from the electronic microbiology laboratory database in our hospital. The isolates responsible for invasive fungal infections, grown in Bact/Allert systems, were identified using chromogenic culture media and VITEK 2 YST ID card system (BioMérieux, France). The e-test was used to determine the minimum inhibitory concentrations (MICs) of fluconazole, voriconazole and anidulafungin, and correlated with EUCAST. Results: A total of 46 invasive Candida isolates were obtained from hospitalized patients during six-year period. C. albicans was the most common species identified in 46% of candidemia cases. In the non-albicans group (54% of all Candida), C. parapsilosis (32%) and C. glabrata (28%) were the most prevalent. All C. albicans were susceptible to voriconazole and anidulafungin, while 12% resistance to fluconazole was detected. On the other hand, voriconazole susceptibility was verified in 94%, and fluconazole in 60% of non-albicans isolates, while only 43% of non-albicans Candida were susceptible to anidulafungin. Reduced susceptibility to anidulafungin in non-albicans group is, in large part, due to predominance of C. parapsilosis. Conclusion: Candida albicans is still the most frequent cause of candidemia, but the frequency of non-albicans species such as C. parapsilosis and C. glabrata, is steadily increasing. Information on recent trends in species distribution and antifungal resistance in local settings is essential to achieve better clinical result and to select an appropriate and effective antifungal therapy.

Candida spp. ; antifungal resistance ; hemoculture

nije evidentirano