engleski

In vitro susceptibility to antibiotics of Escherichia coli isolates in community acquired urinary tract infections

Objectives: To determine in vitro susceptibility of E. coli isolates in community acquired urinary tract infections (CA-UTI) and to suggest optimal empirical antibiotic therapy in these patients. Methods: Three hundred fifthy seven consecutive strains of E. coli isolated from patients with CA-UTI were included in this study. Isolation and identification were performed by standard method and susceptibillity testing was performed by disk diffusion method. Susceptibillity was tested to amoxycillin (AMX), amoxycillin-clavulanate (AMC), cephalexin (CN), cefuroxime (CXM), ceftibuten (CTB), trimethoprim-sulfamethoxazole (STX) and ciprofloxacin (CIP). Results: From total number of 357 strains of E. coli 44.32% were resistant to AMX, 3.92% to AMC, 4.76% to CN, 2.24% to CXM, 0.84% to CTB, 17.09% to STX and 1.77% strains were resistant to ClP. Conclusions: The best in vitro susceptibillity was shown for ceftibuten, followed by ciproftoxacin and cefuroxime. Strains of E. coli show high resistance rate to trimethoprim-sulfamethoxazole and amoxycillin. The antibiotic of the best choice for empirical antibiotic therapy in patients with CA-UTI in our region is ceftibuten. Drugs like trimethaprim-sulphametoxazol or amoxycillin, most often prescribed in empirical therapy of CA-UTI, are not a good choice, because strains of E. coli show high rate of in vitro resistance to these antibiotics.

Escherichia coli ; antibiotics

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