hrvatski

Biološki učinci kapsaicina

Capsaicinoids (capsaicin, dihydrocapsaicin, nordihydrocapsaicin, homodihydrocapsaicin, homocapsaicin, norcapsaicin and nornorcapsaicin) are alkaloids present in Capsicum species responsible for their pungency. In addition, peppers are rich sources of carotenoids, vitamins C and E, and as such, have a wide application in food, medicine and pharmacy. Capsaicin is the most important and the most abundant capsaicinoid. It has been extensively studied for its analgesic, anti-inflammatory, antioxidant, anorexic and anticancer activity. It has been shown that capsaicin alter expression of several genes involved in cancer survival, growth arrest, angiogenesis and metastasis. Its analgesic and pro-apoptotic activity is mediated by transient receptor potential subfamily vanilloid member 1 receptor (TRPV1), while anti-obesity activity is a consequence of expressional changes of neuropeptide Y and cholecystokinin in the arcuate and paraventricular nuclei of hypothalamus. On the other hand, the anticancer activity is mediated through the direct interaction of capsaicin with key signaling molecules of the cytoplasmic, mitochondrial and metabolic survival pathways. Various patches, plasters, creams and capsules with capsaicin or chili pepper extracts are available in the pharmaceutical market.

kapsaicin ; paprika ; karcinom ; anoreksično djelovanje ; analgetsko djelovanje

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