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Pregled bibliografske jedinice broj: 1052185

Biological Effects of Glucosinolate Degradation Products from Horseradish: A Horse that Wins the Race


Popović, Marijana; Maravić, Ana; Čikeš Čulić, Vedrana; Đulović, Azra; Burčul, Franko; Blažević, Ivica
Biological Effects of Glucosinolate Degradation Products from Horseradish: A Horse that Wins the Race // Biomolecules, 10 (2020), 2; 343, 15 doi:10.3390/biom10020343 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1052185 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Biological Effects of Glucosinolate Degradation Products from Horseradish: A Horse that Wins the Race

Autori
Popović, Marijana ; Maravić, Ana ; Čikeš Čulić, Vedrana ; Đulović, Azra ; Burčul, Franko ; Blažević, Ivica

Izvornik
Biomolecules (2218-273X) 10 (2020), 2; 343, 15

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
horseradish ; glucosinolates ; isothiocyanates ; microwave-assisted isolation ; antimicrobial activity ; cytotoxic activity

Sažetak
Horseradish degradation products, mainly isothiocyanates (ITC) and nitriles, along with their precursors glucosinolates, were characterized by GC-MS and UHPLC-MS/MS, respectively. Volatiles from horseradish leaves and roots were isolated using microwave assisted-distillation (MAD), microwave hydrodiffusion and gravity (MHG) and hydrodistillation (HD). Allyl ITC was predominant in the leaves regardless of the isolation method while MAD, MHG, and HD of the roots resulted in different yields of allyl ITC, 2-phenylethyl ITC, and their nitriles. The antimicrobial potential of roots volatiles and their main compounds was assessed against sixteen emerging food spoilage and opportunistic pathogens. The MHG isolate was the most active, inhibiting bacteria at minimal inhibitory concentrations (MICs) from only 3.75 to 30 µg/mL, and fungi at MIC50 between <0.12 and 0.47 µg/mL. Cytotoxic activity of volatile isolates and their main compounds were tested against two human cancer cell lines using MTT assay after 72 h. The roots volatiles showed best cytotoxic activity (HD ; IC50 = 2.62 μg/mL) against human lung A549 and human bladder T24 cancer cell lines (HD ; IC50 = 0.57 μg/mL). Generally, 2-phenylethyl ITC, which was tested for its antimicrobial and cytotoxic activities along with two other major components allyl ITC and 3- phenylpropanenitrile, showed the best biological activities.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija, Farmacija



POVEZANOST RADA


Projekti:
HRZZ-IP-2016-06-1316 - Biljke kao izvor bioaktivnih sumporovih spojeva te njihova sposobnost hiperakumulacije metala (BioSMe) (Blažević, Ivica, HRZZ - 2016-06) ( POIROT)

Ustanove:
Kemijsko-tehnološki fakultet, Split,
Prirodoslovno-matematički fakultet, Split,
Medicinski fakultet, Split

Citiraj ovu publikaciju

Popović, Marijana; Maravić, Ana; Čikeš Čulić, Vedrana; Đulović, Azra; Burčul, Franko; Blažević, Ivica
Biological Effects of Glucosinolate Degradation Products from Horseradish: A Horse that Wins the Race // Biomolecules, 10 (2020), 2; 343, 15 doi:10.3390/biom10020343 (međunarodna recenzija, članak, znanstveni)
Popović, M., Maravić, A., Čikeš Čulić, V., Đulović, A., Burčul, F. & Blažević, I. (2020) Biological Effects of Glucosinolate Degradation Products from Horseradish: A Horse that Wins the Race. Biomolecules, 10 (2), 343, 15 doi:10.3390/biom10020343.
@article{article, year = {2020}, pages = {15}, DOI = {10.3390/biom10020343}, chapter = {343}, keywords = {horseradish, glucosinolates, isothiocyanates, microwave-assisted isolation, antimicrobial activity, cytotoxic activity}, journal = {Biomolecules}, doi = {10.3390/biom10020343}, volume = {10}, number = {2}, issn = {2218-273X}, title = {Biological Effects of Glucosinolate Degradation Products from Horseradish: A Horse that Wins the Race}, keyword = {horseradish, glucosinolates, isothiocyanates, microwave-assisted isolation, antimicrobial activity, cytotoxic activity}, chapternumber = {343} }
@article{article, year = {2020}, pages = {15}, DOI = {10.3390/biom10020343}, chapter = {343}, keywords = {horseradish, glucosinolates, isothiocyanates, microwave-assisted isolation, antimicrobial activity, cytotoxic activity}, journal = {Biomolecules}, doi = {10.3390/biom10020343}, volume = {10}, number = {2}, issn = {2218-273X}, title = {Biological Effects of Glucosinolate Degradation Products from Horseradish: A Horse that Wins the Race}, keyword = {horseradish, glucosinolates, isothiocyanates, microwave-assisted isolation, antimicrobial activity, cytotoxic activity}, chapternumber = {343} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
    • Emerging Sources Citation Index (ESCI)
  • Scopus
  • MEDLINE


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