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Pregled bibliografske jedinice broj: 1052146

Tetracationic bis-triarylborane 1, 3-butadiyne as a combined fluorimetric and Raman probe for simultaneous and selective sensing of various DNA, RNA and proteins


Amini, Hashem; Ban, Željka; Ferger, Matthias; Lorenzen, Sabine; Rauch, Florian; Friedrich, Alexandra; Crnolatac, Ivo; Kenđel, Adriana; Miljanić, Snežana; Piantanida, Ivo; Marder, Todd B.
Tetracationic bis-triarylborane 1, 3-butadiyne as a combined fluorimetric and Raman probe for simultaneous and selective sensing of various DNA, RNA and proteins // Chemistry : a European journal, 26 (2020), 6017-6028 doi:10.1002/chem.201905328 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1052146 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Tetracationic bis-triarylborane 1, 3-butadiyne as a combined fluorimetric and Raman probe for simultaneous and selective sensing of various DNA, RNA and proteins

Autori
Amini, Hashem ; Ban, Željka ; Ferger, Matthias ; Lorenzen, Sabine ; Rauch, Florian ; Friedrich, Alexandra ; Crnolatac, Ivo ; Kenđel, Adriana ; Miljanić, Snežana ; Piantanida, Ivo ; Marder, Todd B.

Izvornik
Chemistry : a European journal (0947-6539) 26 (2020); 6017-6028

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Borane ; Fluorescent probe ; Raman probe ; DNA/RNA Sensor ; Protein Sensor ; Circular Dichroism

Sažetak
A new bis-triarylborane tetracation (4-Ar2B-3, 5-Me2C6H2)-C≡C- C≡C-(3, 5-Me2C6H2-4-BAr2 [Ar = (2, 6-Me2-4-NMe3-C6H2)+] (24+) shows distinctly different behaviour in its fluorimetric response than that of our recently published bis-triarylborane 5- (4-Ar2B-3, 5-Me2C6H2)-2, 2’-(C4H2S)2-5’-(3, 5-Me2C6H2-4-BAr2) (34+). Single-crystal X-ray diffraction data on the neutral bis- triarylborane precursor 2N confirm its rod-like dumbbell structure, which is shown to be important for DNA/RNA targeting and also for BSA protein binding. Fluorimetric titrations with DNA/RNA/BSA revealed the very strong affinity of 24+ and indicated the importance of the properties of the linker connecting the two triarylboranes. Using the butadiyne- rather than a bithiophene linker resulted in an opposite emission effect (quenching vs enhancement), and 24+ bound to BSA 100 times stronger than 34+. Moreover, 24+ interacted strongly with ss-RNA, and circular dichroism (CD) results suggest ss- RNA chain-wrapping around the rod-like bis-triarylborane dumbbell structure like a thread around a spindle, a very unusual mode of binding of ss-RNA with small molecules. Furthermore, 24+ yielded strong Raman/SERS signals, allowing DNA or protein detection at ca. 10 nM concentrations. The above observations, combined with low cytotoxicity, efficient human cell uptake and organelle-selective accumulation make such compounds intriguing novel lead structures for bio-oriented, dual fluorescence/Raman-based applications.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekti:
HRZZ-IP-2018-01-5475 - Višekromoforne probe za prepoznavanje pojedinih struktura DNA, RNA i proteina (BioMultiChromoProbes) (Piantanida, Ivo, HRZZ - 2018-01) ( POIROT)

Ustanove:
Institut "Ruđer Bošković", Zagreb,
Prirodoslovno-matematički fakultet, Zagreb

Citiraj ovu publikaciju

Amini, Hashem; Ban, Željka; Ferger, Matthias; Lorenzen, Sabine; Rauch, Florian; Friedrich, Alexandra; Crnolatac, Ivo; Kenđel, Adriana; Miljanić, Snežana; Piantanida, Ivo; Marder, Todd B.
Tetracationic bis-triarylborane 1, 3-butadiyne as a combined fluorimetric and Raman probe for simultaneous and selective sensing of various DNA, RNA and proteins // Chemistry : a European journal, 26 (2020), 6017-6028 doi:10.1002/chem.201905328 (međunarodna recenzija, članak, znanstveni)
Amini, H., Ban, Ž., Ferger, M., Lorenzen, S., Rauch, F., Friedrich, A., Crnolatac, I., Kenđel, A., Miljanić, S., Piantanida, I. & Marder, T. (2020) Tetracationic bis-triarylborane 1, 3-butadiyne as a combined fluorimetric and Raman probe for simultaneous and selective sensing of various DNA, RNA and proteins. Chemistry : a European journal, 26, 6017-6028 doi:10.1002/chem.201905328.
@article{article, year = {2020}, pages = {6017-6028}, DOI = {10.1002/chem.201905328}, keywords = {Borane, Fluorescent probe, Raman probe, DNA/RNA Sensor, Protein Sensor, Circular Dichroism}, journal = {Chemistry : a European journal}, doi = {10.1002/chem.201905328}, volume = {26}, issn = {0947-6539}, title = {Tetracationic bis-triarylborane 1, 3-butadiyne as a combined fluorimetric and Raman probe for simultaneous and selective sensing of various DNA, RNA and proteins}, keyword = {Borane, Fluorescent probe, Raman probe, DNA/RNA Sensor, Protein Sensor, Circular Dichroism} }
@article{article, year = {2020}, pages = {6017-6028}, DOI = {10.1002/chem.201905328}, keywords = {Borane, Fluorescent probe, Raman probe, DNA/RNA Sensor, Protein Sensor, Circular Dichroism}, journal = {Chemistry : a European journal}, doi = {10.1002/chem.201905328}, volume = {26}, issn = {0947-6539}, title = {Tetracationic bis-triarylborane 1, 3-butadiyne as a combined fluorimetric and Raman probe for simultaneous and selective sensing of various DNA, RNA and proteins}, keyword = {Borane, Fluorescent probe, Raman probe, DNA/RNA Sensor, Protein Sensor, Circular Dichroism} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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