engleski

Risk assessment of obstructive sleep apnea and quality of life in patients with type 2 diabetes

Introduction: Numerous studies suggest that insulin resistance and diabetes type 2 represent important risk factors in the development of obstructive sleep apnea (OSA), as well as OSA being one of the risk factors for type 2 diabetes. The main goal of this study was to assess the risk for OSA in patients with type 2 diabetes and to evaluate overall health-related quality of life among all enrolled patients. Materials and methods: A total of 466 patients with type 2 diabetes (mean age 66.3 years) were consecutively enrolled in this cross-sectional study during the examination at Regional Centre for Diabetes, Endocrinology and Metabolic Diseases of University Hospital of Split. STOP questionnaire (Snoring, Tiredness, Observed, Pressure ; STOP) was used in the evaluation of the risk for OSA, while excessive daytime sleepiness was assessed with the Epworth Sleepiness Scale (ESS). Additionally, all participants completed widely used Short Form- 36 (SF-36) questionnaire which measures health- related quality of life across eight physically and emotionally based domains. Results: Statistical analysis showed that 312 (67%) participants had increased risk for OSA (STOP score ≥ 2), and they had higher body mass index (BMI) (29.6±5.1 vs. 27.02±4.35 kg/m2, P< 0.001), higher neck circumference (38.2±5.0 vs. 37.07±3.7 cm, P=0.003), and higher ESS score (6.5±4.5 vs. 3.99±3.27, P< 0.001) compared to the patients without risk for OSA. In addition, HbA1c values in patients with increased risk for OSA were 8.0±1.81 %, while in patients without risk for OSA they were 7.7±1.79 % (P=0.074). Patients with increased risk for OSA had significantly lower SF-36 scores (P< 0.001 for each of 8 domains). Moreover, overall STOP score showed negative correlation with every domain of the SF-36 survey (P< 0.001). Conclusions: Our study showed that high percentage of patients with type 2 diabetes have increased risk for development of OSA, and those patients have significantly decreased health-related quality of life. Acknowledgements: Study was funded by Croatian Science Foundation project #5935.

OSA ; type 2 diabetes ; quality of life

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