Vaccine Adjuvants Derivatized from Momordica Saponins I and II (CROSBI ID 275799)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Wang, Pengfei ; Ding, Xiong ; Kim, Hyunjung ; Škalamera, Đani ; Michalek, Suzanne M. ; Zhang, Ping
engleski
Vaccine Adjuvants Derivatized from Momordica Saponins I and II
We have derivatized Momordica saponins (MS) I and II through their coupling at C3 glucuronic acid site with dodecylamine. The derivatives show significantly different immunostimulant activity profiles from their respective natural parent saponins. In particular, adjuvant VSA-1 (5), the derivative of MS I, potentiates a significantly higher IgG2a responose than the corresponding natural product. Its IgG1 and IgG2a production is similar to that of GPI- 0100, indicating a potential mixed and antigen- specific Th1/Th2 immune response, which is different from the Th2 immunity induced by the natural saponin MS I. In addition, toxicity evaluations show that adjuvant VSA-1 (5) is much less toxic than the widely used natural saponin mixture Quil A. These results prove that derivatizing Momordica saponins can be a viable way for easy access to structurally defined saponin immunostimulants with favorable adjvuant activity and low toxicity.
immunoadjuvants, Momordica saponins, organic synthesis, carbohydrate chemistry, natural product synthesis
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o izdanju
62 (21)
2019.
9976-9982
objavljeno
0022-2623
1520-4804
10.1021/acs.jmedchem.9b01511
Povezanost rada
Interdisciplinarne prirodne znanosti, Kemija