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Pregled bibliografske jedinice broj: 1050949

Expression of ferritin light and heavy chains in rat liver: sex and age differences


Pavić, Mirela; Turčić, Petra; Antolić, Nikolina; Karaica, Dean; Vrhovac Madunić, Ivana; Micek, Vedran; Breljak, Davorka; Ljubojević, Marija
Expression of ferritin light and heavy chains in rat liver: sex and age differences // Book of Abstracts "9th Croatian Congress of Pharmacology with International Participation"
Zagreb, 2019. str. 137-137 (poster, domaća recenzija, sažetak, znanstveni)


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Naslov
Expression of ferritin light and heavy chains in rat liver: sex and age differences

Autori
Pavić, Mirela ; Turčić, Petra ; Antolić, Nikolina ; Karaica, Dean ; Vrhovac Madunić, Ivana ; Micek, Vedran ; Breljak, Davorka ; Ljubojević, Marija

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of Abstracts "9th Croatian Congress of Pharmacology with International Participation" / - Zagreb, 2019, 137-137

Skup
9th Croatian Congress of Pharmacology with International Participation

Mjesto i datum
Zagreb, Hrvatska, 25.-28.09.2019

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
ferritin, sex differences, age differences, liver, rat

Sažetak
Introduction: The ferritin complex consists of two protein chains structured in a 24 subunit nanocage for iron storage. Very early research on liver in experimental animals found sex differences in favor of females in the amount of iron, which was later associated with sex differences in the ferritin amount in the liver as an iron storage organ. Materials and Methods: We used specific antibodies for two ferritin subunits followed by immunochemical methods for sex and age differences in the expression of light and heavy subunits of ferritin in the liver of three-month and two-year old Wistar rats together with gonadectomized three-month animals for steroid hormone influence determination. Distribution of ferritin subunits inside the organ was obtained by immunohistochemistry, while differences in the expression of individual subunits were determined by western analysis. Results: The results of immunochemical analyses confirmed sex differences in both ferritin subunits and these remained with age, while the amount of ferritin in liver increased with age. Gonadectomy showed a positive effect of estrogen on the expression of both chains and a negative of testosterone. Both ferritin subunits displayed an overlapping distribution in liver cells, which was most pronounced in hepatocytes around the central veins. Conclusion: We can conclude that both ferritin subunits were expressed in the liver and showed sex differences influenced by steroid hormones and age differences which may be correlated with an enlarged amount of stored iron and thus with a great threat of increased oxidative stress crucial to the pathophysiological mechanisms of the aging process.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Veterinarska medicina, Farmacija



POVEZANOST RADA


Projekt / tema
CSF grant IP-11-2013-1481 - CSF grant IP-11-2013-1481

Ustanove
Farmaceutsko-biokemijski fakultet, Zagreb,
Institut za medicinska istraživanja i medicinu rada, Zagreb,
Veterinarski fakultet, Zagreb

Citiraj ovu publikaciju

Pavić, Mirela; Turčić, Petra; Antolić, Nikolina; Karaica, Dean; Vrhovac Madunić, Ivana; Micek, Vedran; Breljak, Davorka; Ljubojević, Marija
Expression of ferritin light and heavy chains in rat liver: sex and age differences // Book of Abstracts "9th Croatian Congress of Pharmacology with International Participation"
Zagreb, 2019. str. 137-137 (poster, domaća recenzija, sažetak, znanstveni)
Pavić, M., Turčić, P., Antolić, N., Karaica, D., Vrhovac Madunić, I., Micek, V., Breljak, D. & Ljubojević, M. (2019) Expression of ferritin light and heavy chains in rat liver: sex and age differences. U: Book of Abstracts "9th Croatian Congress of Pharmacology with International Participation".
@article{article, year = {2019}, pages = {137-137}, keywords = {ferritin, sex differences, age differences, liver, rat}, title = {Expression of ferritin light and heavy chains in rat liver: sex and age differences}, keyword = {ferritin, sex differences, age differences, liver, rat}, publisherplace = {Zagreb, Hrvatska} }




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