Multicomponent Approach to Homo- and Hetero- Multivalent Glycomimetics Bearing Rare Monosaccharides (CROSBI ID 275508)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Jakas, Andreja ; Višnjevac, Aleksandar ; Jerić, Ivanka
engleski
Multicomponent Approach to Homo- and Hetero- Multivalent Glycomimetics Bearing Rare Monosaccharides
We applied a multicomponent approach to access a library of densely functionalized homo- and hetero-multivalent glycomimetics comprising aldehyde, amine, and isocyanide components related to isopropylidene-protected d-fructose, l-sorbose, d-galactose, and d-allose. Passerini products were obtained in very good yields (up to 78%) and high diastereoselectivities (up to 98:2). Three types of products were obtained by the Ugi reaction ; along with the “classical” four-component product, α-acylaminoamides, a three-component α-aminoamides, and a four- component α-aminoacylamides were isolated. The presence of multiple pathways is rationalized by the structure of the imidate intermediate, mainly influenced by the amine component.
multicomponent reactions ; glycoconjugates ; multivalent ligands ; heterovalent ligands ; carbohydrates
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Podaci o izdanju
85 (5)
2020.
3766-3787
objavljeno
0022-3263
1520-6904
10.1021/acs.joc.9b03401