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Pregled bibliografske jedinice broj: 1050235

Pregnancy exposome and child psychomotor development in three European birth cohorts


(EU FP7 HEALS) Calamandrei, Gemma; Ricceri, Laura; Meccia, Ettore; Tartaglione, Anna Maria; Horvat, Milena; Tratnik, Janja Snoj; Mazej, Darja; Špirić, Zdravko; Prpić, Igor; Vlašić-Cicvarić, Inge et al.
Pregnancy exposome and child psychomotor development in three European birth cohorts // Environmental Research, 181 (2020), 108856, 6 doi:10.1016/j.envres.2019.108856 (međunarodna recenzija, članak, znanstveni)


Naslov
Pregnancy exposome and child psychomotor development in three European birth cohorts

Autori
Calamandrei, Gemma ; Ricceri, Laura ; Meccia, Ettore ; Tartaglione, Anna Maria ; Horvat, Milena ; Tratnik, Janja Snoj ; Mazej, Darja ; Špirić, Zdravko ; Prpić, Igor ; Vlašić-Cicvarić, Inge ; Neubauer, David ; Kodrič, Jana ; Stropnik, Staša ; Janasik, Beata ; Kuraś, Renata ; Mirabella, Fiorino ; Polańska, Kinga ; Chiarotti, Flavia

Kolaboracija
EU FP7 HEALS

Izvornik
Environmental Research (0013-9351) 181 (2020); 108856, 6

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Prenatal exposure ; Developmental neurotoxicity ; Metals ; Micronutrients

Sažetak
Characterization of the exposome, the totality of all environmental factors that one is exposed to from conception onwards, has been recommended to better evaluate the role of environmental influences on developmental programming and life- course vulnerability to major chronic diseases. In the framework of the Health and Environment- wide Associations based on Large population Surveys (HEALS) project we considered the pregnancy exposome exploiting two databases (PRIME and REPRO PL) that include birth cohorts from three EU countries (Croatia, Slovenia and Poland). The databases contained information on several chemical exposures, socio-demographic, lifestyle and health related factors from conception to child birth, and neuropsychological scores assessed by the Bayley Scales of Infant and Toddler Development in the first two years of life. Our main goal was to assess consistency of environmental influences on neurodevelopment, if any, across European countries differing for geographical, socio-demographic characteristics and levels of chemical exposures to metals such as lead (Pb), mercury (Hg), cadmium (Cd) and trace elements, including micronutrients such as zinc (Zn) and selenium (Se). To this aim, we first selected variables common to the different databases, then applied univariate and multivariate regression analyses to identify factors linked to neurodevelopment, and finally performed meta-analysis to detect potential heterogeneity among cohorts and pooled estimates. Significant differences in exposure levels among the three sub-cohorts were observed as for Hg and Se ; exposure levels under study were relatively low and within the range described in existing EU biomonitoring studies. The univariate analyses did not show any common pattern of association as only in the Polish cohort chemical exposure had an impact on neuropsychological outcome. In the meta-analysis, some consistent trends were evident, relative to the adverse influence of Pb on children's language and cognition and the positive influence of Se on language abilities. The effects of the neurotoxic metal Hg positively influenced the motor scores in the Polish cohorts, while it decreased the motor scores in the Slovenia and Croatian sub-cohorts. The only socio-demographic factor consistently associated to the outcome among cohorts was child's sex, with females performing better than males on cognitive and language scores. These findings point to the need of harmonizing existing cohorts or creating prospective study designs that facilitate comparisons in the exposome over time, places and kind of environmental exposures.

Izvorni jezik
Engleski

Znanstvena područja
Biotehnologija



POVEZANOST RADA


Projekt / tema
273-0222882-2698 - Bioindikacija onečišćenja zraka u terestričkim ekosustavima (Zdravko Špirić, )

Ustanove
Medicinski fakultet, Rijeka,
Klinički bolnički centar Rijeka

Citiraj ovu publikaciju

(EU FP7 HEALS) Calamandrei, Gemma; Ricceri, Laura; Meccia, Ettore; Tartaglione, Anna Maria; Horvat, Milena; Tratnik, Janja Snoj; Mazej, Darja; Špirić, Zdravko; Prpić, Igor; Vlašić-Cicvarić, Inge et al.
Pregnancy exposome and child psychomotor development in three European birth cohorts // Environmental Research, 181 (2020), 108856, 6 doi:10.1016/j.envres.2019.108856 (međunarodna recenzija, članak, znanstveni)
(EU FP7 HEALS) (EU FP7 HEALS) Calamandrei, G., Ricceri, L., Meccia, E., Tartaglione, A., Horvat, M., Tratnik, J., Mazej, D., Špirić, Z., Prpić, I. & Vlašić-Cicvarić, I. (2020) Pregnancy exposome and child psychomotor development in three European birth cohorts. Environmental Research, 181, 108856, 6 doi:10.1016/j.envres.2019.108856.
@article{article, year = {2020}, pages = {6}, DOI = {10.1016/j.envres.2019.108856}, chapter = {108856}, keywords = {Prenatal exposure, Developmental neurotoxicity, Metals, Micronutrients}, journal = {Environmental Research}, doi = {10.1016/j.envres.2019.108856}, volume = {181}, issn = {0013-9351}, title = {Pregnancy exposome and child psychomotor development in three European birth cohorts}, keyword = {Prenatal exposure, Developmental neurotoxicity, Metals, Micronutrients}, chapternumber = {108856} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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