engleski

Synthesis and characterization of macrozones, new bioactive azithromycin conjugates

Macrolide antibiotics, such as azithromycin, have been widely prescribed for the treatment of respiratory tract infections owing to their high efficacy and safety.[1] Azithromycin belongs to an azalide subclass of 15-membered macrolide antibiotics. Emerging multi-drug resistant microbial pathogens present today a serious and challenging global problem which demands novel and more effective antimicrobial agents to be discovered. Thiosemicarbazones and some of their metal complexes have been shown to possess anti- infective, anti-inflammatory and antitumor activities. Some thiosemicarbazones have proven very useful to treat infections, such as the new antibiotics perchlozone and thiacetazone, which are good new agents against tuberculosis.[2] Our earlier experiments which included synthesis and biological and structural characterization of some macrolide conjugates showed that those hybrid compounds exhibited good activity against some resistant bacterial strains.[3-4] Here, we present synthesis and characterization of novel macrolide conjugates, the macrozones by linking azithromycin and some selected thiosemicarbazones.

macrozones, azithromycin, thiosemicarbazides, synthesis

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