engleski

Effect of omega-3 supplements on plasma apolipoprotein C-III concentrations: a systematic review and meta-analysis of randomized controlled trials

Background: Apolipoprotein C-III (apo C-III) is a key regulator of triglycerides metabolism. The aim of this meta-analysis was to assess the effect of fish omega-3 polyunsaturated fatty acids (PUFAs) on apo C-III levels.Methods: Randomized placebo- controlled trials investigating the impact of omega-3 on apo C- III levels were searched in PubMed-Medline, SCOPUS, Web of Science and Google Scholar. A random-effects model and generic inverse variance method were used for quantitative data synthesis. Sensitivity analysis was conducted using the leave-one-out method. A weighted random- effects meta-regression was performed to evaluate the impact of potential confounders on glycemic parameters.Results: This meta-analysis comprising 2062 subjects showed a significant reduction of apo C-III concentrations following treatment with omega-3 (WMD: -22.18mg/L, 95% confidence interval: -31.61, -12.75, p<.001 ; I- 2: 88.24%). Subgroup analysis showed a significant reduction of plasma apo C-III concentrations by eicosapentaenoic acid (EPA) ethyl esters but not omega-3 carboxylic acids or omega-3 ethyl esters. There was a greater apo C-III reduction with only EPA as compared with supplements containing EPA and docosahexaenoic acid (DHA) or only DHA. A positive association between the apo C-III- lowering effect of omega-3 with baseline apo C- III concentrations and treatment duration was found.Conclusions: This meta-analysis has shown that omega-3 PUFAs might significantly decrease apo C-III.

Omega-3 fatty acids ; PUFA ; eicosapentaenoic acid ; docosahexaenoic acid ; cardiovascular disease ; coronary heart disease

nije evidentirano