Determination of ethyl-phenyl macrozone reaction mixture components by LC-SPE/NMR methodology (CROSBI ID 687989)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Habinovec, Iva ; Novak, Predrag ; Benčić, Noelle ; Mikulandra, Ivana ; Lulić, Ana-Marija ; Grgičević, Ivan ; Bukvić, Mirjana ; Zangger, Klaus
engleski
Determination of ethyl-phenyl macrozone reaction mixture components by LC-SPE/NMR methodology
Azithromycin is the most widely used broad- spectrum antibiotic due to it's exceptional therapeutic properties.[1] Despite to this fact, an increasing number of antibiotic- resistant bacteria demands more effective antimicrobial agents to be synthesized.[2] Third generation of macrolide antibiotics still lacks activity against some Gram-negative bacterial strains, especially against respiratory tract pathogens. In order to improve antibacterial activity, new synthetic approaches were described in the literature.[3] Conjugation of the azithromycin analogue, 9a- (γ-aminopropyl) derivative, and thiosemicarbazide moieties resulted in novel compounds, macrozones, which showed good in vitro activity against selected Gram positive and Gram negative bacterial strains. Preparative and semi-preparative liquid chromatography are classical methods for purification and isolation of the final product, but they are time and solvent consuming. Modern hyphenated NMR techniques, such as LC-SPE/cryoNMR, are much faster, more efficient and more sensitive tool for the isolation and identification of the reaction mixture components. [4, 5] In this study LC- SPE/cryoNMR technique was used for the isolation of a novel ethyl-phenyl macrozone and for impurity profiling of the reaction mixture.
macrozones ; azithromycin ; thiosemicarbazides ; LC-SPE-NMR
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Podaci o prilogu
61-61.
2019.
objavljeno
Podaci o matičnoj publikaciji
Adriatic NMR conference : Book of Abstracts
Namjesnik, Danijel ; Novak, Predrag ; Parlov-Vuković, Jelena
Zagreb: Kemijski odsjek Prirodoslovno-matematičkog fakulteta Sveučilišta u Zagrebu ; Geološki odsjek Prirodoslovno-matematičkog fakulteta Sveučilišta u Zagrebu
978-953-6076-56-7
Podaci o skupu
Adriatic NMR 2019
poster
06.06.2019-09.06.2019
Mali Ston, Hrvatska