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Pregled bibliografske jedinice broj: 1050150

Continuing war on pain: a personalized approach to the therapy with nonsteroidal anti- inflammatory drugs and opioids


Bach-Rojecky, Lidija; Vađunec, Dalia; Žunić, Katarina; Kurija, Jelena; Šipicki, Sara; Gregg, Ryan; Mikula, Ivan; Primorac, Dragan
Continuing war on pain: a personalized approach to the therapy with nonsteroidal anti- inflammatory drugs and opioids // Personalized Medicine, 16 (2019), 2; 171-184 doi:10.2217/pme-2018-0116 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1050150 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Continuing war on pain: a personalized approach to the therapy with nonsteroidal anti- inflammatory drugs and opioids

Autori
Bach-Rojecky, Lidija ; Vađunec, Dalia ; Žunić, Katarina ; Kurija, Jelena ; Šipicki, Sara ; Gregg, Ryan ; Mikula, Ivan ; Primorac, Dragan

Izvornik
Personalized Medicine (1741-0541) 16 (2019), 2; 171-184

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
analgesic effect ; epigenetics ; genes ; nonsteroidal anti-inflammatory drugs ; opioids ; pain treatment ; pharmacogenetics ; side effects ; toxicity

Sažetak
Successful pain management requires the delivery of analgesia with minimal risk of adverse drug reactions. Nonsteroidal anti- inflammatory drugs and opioids remain the mainstay of treatment for the majority of patients. Unfortunately, almost 50% of all patients experience inadequate pain relief and serious side effects. Allelic variants in genes coding for target proteins, transporters and enzymes, which govern analgesic drugs action and their fate in the organism, might explain inter-individual variability in pain severity and in drug-induced pain relief and toxicities. Additionally, it seems that epigenetic changes contribute to the highly variable response to pain treatment. Therefore, pharmacogenomic testing might be a valuable tool for personalization of pain treatment, with a multidisciplinary team approach involved

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Farmacija



POVEZANOST RADA


Ustanove
Medicinski fakultet, Rijeka,
Medicinski fakultet, Split,
Fakultet za dentalnu medicinu i zdravstvo, Osijek

Profili:

Avatar Url Ivan Mikula (autor)

Avatar Url Dragan Primorac (autor)

Avatar Url Lidija Bach-Rojecky (autor)

Citiraj ovu publikaciju

Bach-Rojecky, Lidija; Vađunec, Dalia; Žunić, Katarina; Kurija, Jelena; Šipicki, Sara; Gregg, Ryan; Mikula, Ivan; Primorac, Dragan
Continuing war on pain: a personalized approach to the therapy with nonsteroidal anti- inflammatory drugs and opioids // Personalized Medicine, 16 (2019), 2; 171-184 doi:10.2217/pme-2018-0116 (međunarodna recenzija, članak, znanstveni)
Bach-Rojecky, L., Vađunec, D., Žunić, K., Kurija, J., Šipicki, S., Gregg, R., Mikula, I. & Primorac, D. (2019) Continuing war on pain: a personalized approach to the therapy with nonsteroidal anti- inflammatory drugs and opioids. Personalized Medicine, 16 (2), 171-184 doi:10.2217/pme-2018-0116.
@article{article, year = {2019}, pages = {171-184}, DOI = {10.2217/pme-2018-0116}, keywords = {analgesic effect, epigenetics, genes, nonsteroidal anti-inflammatory drugs, opioids, pain treatment, pharmacogenetics, side effects, toxicity}, journal = {Personalized Medicine}, doi = {10.2217/pme-2018-0116}, volume = {16}, number = {2}, issn = {1741-0541}, title = {Continuing war on pain: a personalized approach to the therapy with nonsteroidal anti- inflammatory drugs and opioids}, keyword = {analgesic effect, epigenetics, genes, nonsteroidal anti-inflammatory drugs, opioids, pain treatment, pharmacogenetics, side effects, toxicity} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
  • Scopus


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