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Pregled bibliografske jedinice broj: 1049705

Early results of intra-articular micro- fragmented lipoaspirate treatment in patients with late stages knee osteoarthritis: a prospective study


Hudetz, Damir; Boric, Igor; Rod, Eduard; Jelec, Zeljko; Kunovac, Barbara; Polasek, Ozren; Vrdoljak, Trpimir; Plecko, Mihovil; Skelin, Andrea; Polancec, Denis et al.
Early results of intra-articular micro- fragmented lipoaspirate treatment in patients with late stages knee osteoarthritis: a prospective study // Croatian medical journal, 60 (2019), 3; 227-236 (domaća recenzija, članak, znanstveni)


CROSBI ID: 1049705 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Early results of intra-articular micro- fragmented lipoaspirate treatment in patients with late stages knee osteoarthritis: a prospective study

Autori
Hudetz, Damir ; Boric, Igor ; Rod, Eduard ; Jelec, Zeljko ; Kunovac, Barbara ; Polasek, Ozren ; Vrdoljak, Trpimir ; Plecko, Mihovil ; Skelin, Andrea ; Polancec, Denis ; Zenic, Lucija ; Primorac, Dragan

Izvornik
Croatian medical journal (0353-9504) 60 (2019), 3; 227-236

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
MESENCHYMAL STEM-CELLS ; ENDOTHELIAL PROGENITOR CELLS ; INJECTIONS

Sažetak
Aim To analyze clinical and functional effects of intra-articular injection of autologous micro-fragmented lipoaspirate (MLA) in patients with late stage knee osteoarthritis (KOA). Secondary aims included classifying cell types contributing to the treatment effect, performing detailed MRI-based classification of KOA, and elucidating the predictors for functional outcomes. Methods This prospective, non-randomized study was conducted from June 2016 to February 2018 and enrolled 20 patients with late stage symptomatic KOA (Kellgren Lawrence grade III, n = 4 ; and IV, n = 16) who received an intra- articular injection of autologous MLA in the index knee joint. At baseline radiological KOA grade and MRI were assessed in order to classify the morphology of KOA changes. Stromal vascular fraction cells obtained from MLA samples were stained with antibodies specific for cell surface markers. Patients were evaluated at baseline and 12-months after treatment with visual analog scale (VAS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and Knee Injury and Osteoarthritis Outcome Score (KOOS). Results Three patients (15%) received a total knee replacement and were not followed up completely. Seventeen patients (85%) showed a substantial pattern of KOOS and WOMAC improvement, significant in all accounts. KOOS score improved from 46 to 176% when compared with baseline, WOMAC decreased from 40 to 45%, while VAS rating decreased from 54% to 82% (all P values were < 0.001). MLA contained endothelial progenitor cells, pericytes, and supra-adventitial adipose stromal cells as most abundant cell phenotypes. Conclusion This study is among the first to show a positive effect of MLA on patients with late stages KOA.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove
Medicinski fakultet, Rijeka,
Medicinski fakultet, Zagreb,
Fakultet za dentalnu medicinu i zdravstvo, Osijek

Citiraj ovu publikaciju

Hudetz, Damir; Boric, Igor; Rod, Eduard; Jelec, Zeljko; Kunovac, Barbara; Polasek, Ozren; Vrdoljak, Trpimir; Plecko, Mihovil; Skelin, Andrea; Polancec, Denis et al.
Early results of intra-articular micro- fragmented lipoaspirate treatment in patients with late stages knee osteoarthritis: a prospective study // Croatian medical journal, 60 (2019), 3; 227-236 (domaća recenzija, članak, znanstveni)
Hudetz, D., Boric, I., Rod, E., Jelec, Z., Kunovac, B., Polasek, O., Vrdoljak, T., Plecko, M., Skelin, A. & Polancec, D. (2019) Early results of intra-articular micro- fragmented lipoaspirate treatment in patients with late stages knee osteoarthritis: a prospective study. Croatian medical journal, 60 (3), 227-236.
@article{article, year = {2019}, pages = {227-236}, keywords = {MESENCHYMAL STEM-CELLS, ENDOTHELIAL PROGENITOR CELLS, INJECTIONS}, journal = {Croatian medical journal}, volume = {60}, number = {3}, issn = {0353-9504}, title = {Early results of intra-articular micro- fragmented lipoaspirate treatment in patients with late stages knee osteoarthritis: a prospective study}, keyword = {MESENCHYMAL STEM-CELLS, ENDOTHELIAL PROGENITOR CELLS, INJECTIONS} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE





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