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Pregled bibliografske jedinice broj: 1049599

Thymus Regeneration and Future Challenges


Shichkin, Valentin P.; Antica, Mariastefania
Thymus Regeneration and Future Challenges // Stem cell reviews and reports, 16 (2020), 239-250 doi:10.1007/s12015-020-09955-y (međunarodna recenzija, članak, znanstveni)


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Naslov
Thymus Regeneration and Future Challenges

Autori
Shichkin, Valentin P. ; Antica, Mariastefania

Izvornik
Stem cell reviews and reports (2629-3269) 16 (2020); 239-250

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Stem cells ; Thymus ; Thymectomised patients ; Thymus regeneration ; Thymic epithelial stem cells ; Small chemical compounds

Sažetak
Thymus regenerative therapy implementation is severely obstructed by the limited number and expansion capacity in vitro of tissue-specific thymic epithelial stem cells (TESC). Current solutions are mostly based on growth factors that can drive differentiation of pluripotent stem cells toward tissue-specific TESC. Target-specific small chemical compounds represent an alternative solution that could induce and support the clonal expansion of TESC and reversibly block their differentiation into mature cells. These compounds could be used both in the composition of culture media designed for TESC expansion in vitro, and in drugs development for thymic regeneration in vivo. It should allow reaching the ultimate objective - autologous thymic tissue regeneration in paediatric patients who had their thymus removed in the course of cardiac surgery.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Ustanove
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Mariastefania Antica (autor)

Citiraj ovu publikaciju

Shichkin, Valentin P.; Antica, Mariastefania
Thymus Regeneration and Future Challenges // Stem cell reviews and reports, 16 (2020), 239-250 doi:10.1007/s12015-020-09955-y (međunarodna recenzija, članak, znanstveni)
Shichkin, V. & Antica, M. (2020) Thymus Regeneration and Future Challenges. Stem cell reviews and reports, 16, 239-250 doi:10.1007/s12015-020-09955-y.
@article{article, year = {2020}, pages = {239-250}, DOI = {10.1007/s12015-020-09955-y}, keywords = {Stem cells, Thymus, Thymectomised patients, Thymus regeneration, Thymic epithelial stem cells, Small chemical compounds}, journal = {Stem cell reviews and reports}, doi = {10.1007/s12015-020-09955-y}, volume = {16}, issn = {2629-3269}, title = {Thymus Regeneration and Future Challenges}, keyword = {Stem cells, Thymus, Thymectomised patients, Thymus regeneration, Thymic epithelial stem cells, Small chemical compounds} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


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