engleski

Significance of ionized magensium determniation in assessment of clinical status of pediatric patients.

The knowledge of omporatnce of magnesium, the seond intracellular catio according to its frequency, is coninuously increasing. Izs role in cellular metabolism is the issue of numerous stidies. There is only 1% of extracellular magnesium in the body. Serum determination of the amount of ionized magnesium as an important cofactor in numerous enzymatic processes indirectly reflects the activity of cellular magnesium. The level f ionized magnezium in subjects from pediatric population was determined in this prospective study. The points of interests werw as followed: 1. diseases that involve hypomagnesiaemina, 2. diseases with acute or chronc course, 3. severity of clinical condition at admission. Lowerwd ionised magnesium value was registered in one third of our subjects (reference range 0.54-0.65 mmoL/L). Gastrointestinal simptomatology was registered in 50% of our subjects with hypomagnesiaemia, respiratory simptoms were established in one fourth of subjects, while heterogenous clinical conditions were present in the remaining fourth of subjects. Hypomagnesiaemia was corelatted in children with gastrointestinal simptoms according to the presence of clinical events. Diseases with chronic course werw detected in 83% of patients, while the remaining 17% manifested acute gastrointestinal tract disorder. Hypomagnesiaemia accompanying an acute respiratory disease was established in children with respiratory simptomatollogy. In relation to the severity of clinical cndition, deteriorated general condition was registered in 40% of hypomagnesiaemic subjects, while the clinical status of remaining subjects could be caracterized as moderatly to slightly deteriorated. In conclusion, our results indicate that the patients at risk for hypomagnesiaemia are children with chronic gastrointestinal diseases (malapsorption, vomiting) while possible interventions include nutritive supplementation or drug prophylaxis.

magnesium; hypomagnesiaemia

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