Modulation of innate and adaptive immunity by cytomegaloviruses (CROSBI ID 275063)
Prilog u časopisu | pregledni rad (znanstveni) | međunarodna recenzija
Podaci o odgovornosti
Berry, R.; Watson, G.M.; Jonjić, Stipan; Degli-Esposti, M.; Rossjohn, J.
engleski
Modulation of innate and adaptive immunity by cytomegaloviruses
The coordinated activities of innate and adaptive immunity are critical for effective protection against viruses. To counter this, some viruses have evolved sophisticated strategies to circumvent immune cell recognition. In particular, cytomegaloviruses encode large arsenals of molecules that seek to subvert T cell and natural killer cell function via a remarkable array of mechanisms. Consequently, these ‘immunoevasins’ play a fundamental role in shaping the nature of the immune system by driving the evolution of new immune receptors and recognition mechanisms. Here, we review the diverse strategies adopted by cytomegaloviruses to target immune pathways and outline the host’s response.
cytomegalovirus; immunity
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Podaci o izdanju
20
2020.
113-127
objavljeno
1474-1733
1474-1741
10.1038/s41577-019-0225-5
Povezanost rada
Temeljne medicinske znanosti