engleski

Lymphatic and glymphatic systems as origin points for Alzheimer’s disease

Until recently the central nervous system was considered to lack a system of lymphatic vessels that drains interstitial fluid and allows circulation of immunocompetent cells, but this view changed when lymphatic vessels where described in the mouse brain (Louveau et al., Nature 2015 ; 523: 337-41). Most of these lymphatic vessels are aligned along the transverse and the upper sagittal sinuses, and contain cerebrospinal fluid (CSF), T lymphocytes, and dendritic cells. It was also demonstrated that these meningeal lymphatic vessels drain into the deep lymph nodes of the neck using Evan’s Blue (Louveau et al., Nature 2015 ; 523: 337-41). Therefore, dysregulation or disruption of the blood-brain barrier and the glymphatic and lymphatic systems harbors the potential to contribute to the development of neurodegenerative diseases, particularly AD, and represent a potentially important and accessible target for the treatment of AD, and other neurodegenerative conditions.

Alzheimer's disease ; central nervous system ; glymphatic system ; lymphatic vessels ; blood-brain barrier

nije evidentirano