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Evaluation of the diabetogenic effect of methotrexate in psoriatic arthritis patients with metabolic syndrome: a pilot study


Dehpouri, Tannaz; Rahmatpour Rokni, Ghasem; Ahangar Narenjbon, Nematollah; Goldust, Mohamad; Yamauchi, Paul S.; Wollina, Uwe; Lotti, Torello; Kircik, Leon; Di Lernia, Vito Giuseppe; Sonthalia, Sidharth et al.
Evaluation of the diabetogenic effect of methotrexate in psoriatic arthritis patients with metabolic syndrome: a pilot study // Dermatology Reports, 11 (2019), 1; 7965, 5 doi:10.4081/dr.2019.7965 (međunarodna recenzija, članak, znanstveni)


Naslov
Evaluation of the diabetogenic effect of methotrexate in psoriatic arthritis patients with metabolic syndrome: a pilot study

Autori
Dehpouri, Tannaz ; Rahmatpour Rokni, Ghasem ; Ahangar Narenjbon, Nematollah ; Goldust, Mohamad ; Yamauchi, Paul S. ; Wollina, Uwe ; Lotti, Torello ; Kircik, Leon ; Di Lernia, Vito Giuseppe ; Sonthalia, Sidharth ; Vojvodic, Alexandra ; Szepietowski, Jacek ; Bahadoran, Philippe ; Errichetti, Enzo ; Cantisani, Carmen ; Atzori, Laura ; Rezaee, Elham ; Kutlubay, Zekayi ; Engin, Burhan ; Nisticò, Steven ; Damiani, Giovanni ; Conic, Rosalynn R.Z. ; Goren, Andy ; Čabrijan, Leo ; Tchernev, Georgi

Izvornik
Dermatology Reports (2036-7392) 11 (2019), 1; 7965, 5

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
HbA1c ; Metabolic syndrome ; Methotrexate ; Psoriatic arthritis

Sažetak
Methotrexate (MTX) is a systemic immunosuppressant drug used for the treatment of psoriasis and psoriatic arthritis. Previous studies demonstrated a potential association between psoriasis and diabetes mellitus, obesity, atherosclerosis, hypertension, eventuating into metabolic syndrome. This study aimed at exploring the glycemic effects of MTX in psoriatic arthritis (PsA) patients. In this prospective cross-sectional study, 27 patients with PsA were evaluated. The status of PsA and presence of accompanying metabolic syndrome was determined by standard criteria and indices. Blood indicators including HbA1c, erythrocyte sedimentation rate, fasting blood sugar, total cholesterol, high-density lipoprotein, triglycerides, and C-reactive protein were examined before and 12 weeks after MTX therapy. There were no significant changes between HbA1c levels before and after MTX therapy in both genders (men: P=0.131, women: P=0.803). In addition, HbA1c levels in PsA patients with metabolic syndrome were not different before and after treatment (P=0.250). Finally, HbA1c levels did not change in PsA patients without metabolic syndrome before and after therapy (P=0.506). MTX in PsA patients does not appear to have hyperglycaemic effects in the short-term and can be safely used in patients with metabolic syndrome and diabetes.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove
Medicinski fakultet, Rijeka,
Klinički bolnički centar Rijeka

Profili:

Avatar Url Leo Čabrijan (autor)

Citiraj ovu publikaciju

Dehpouri, Tannaz; Rahmatpour Rokni, Ghasem; Ahangar Narenjbon, Nematollah; Goldust, Mohamad; Yamauchi, Paul S.; Wollina, Uwe; Lotti, Torello; Kircik, Leon; Di Lernia, Vito Giuseppe; Sonthalia, Sidharth et al.
Evaluation of the diabetogenic effect of methotrexate in psoriatic arthritis patients with metabolic syndrome: a pilot study // Dermatology Reports, 11 (2019), 1; 7965, 5 doi:10.4081/dr.2019.7965 (međunarodna recenzija, članak, znanstveni)
Dehpouri, T., Rahmatpour Rokni, G., Ahangar Narenjbon, N., Goldust, M., Yamauchi, P., Wollina, U., Lotti, T., Kircik, L., Di Lernia, V. & Sonthalia, S. (2019) Evaluation of the diabetogenic effect of methotrexate in psoriatic arthritis patients with metabolic syndrome: a pilot study. Dermatology Reports, 11 (1), 7965, 5 doi:10.4081/dr.2019.7965.
@article{article, year = {2019}, pages = {5}, DOI = {10.4081/dr.2019.7965}, chapter = {7965}, keywords = {HbA1c, Metabolic syndrome, Methotrexate, Psoriatic arthritis}, journal = {Dermatology Reports}, doi = {10.4081/dr.2019.7965}, volume = {11}, number = {1}, issn = {2036-7392}, title = {Evaluation of the diabetogenic effect of methotrexate in psoriatic arthritis patients with metabolic syndrome: a pilot study}, keyword = {HbA1c, Metabolic syndrome, Methotrexate, Psoriatic arthritis}, chapternumber = {7965} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Emerging Sources Citation Index (ESCI)
  • Scopus


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