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Pregled bibliografske jedinice broj: 1048826

Decreased immunoglobulin G core fucosylation, a player in antibody-dependent cell-mediated cytotoxicity, is associated with autoimmune thyroid diseases


Martin, Tiphaine C; Šimurina, Mirna; Ząbczyńska, Marta; Martinic Kavur, Marina; Rydlewska, Magdalena; Pezer, Marija; Kozłowska, Kamila; Burri, Andrea; Vilaj, Marija; Turek-Jabrocka, Renata et al.
Decreased immunoglobulin G core fucosylation, a player in antibody-dependent cell-mediated cytotoxicity, is associated with autoimmune thyroid diseases // Molecular & cellular proteomics, 2020 (2020), x, 64 doi:10.1074/mcp.ra119.001860 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1048826 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Decreased immunoglobulin G core fucosylation, a player in antibody-dependent cell-mediated cytotoxicity, is associated with autoimmune thyroid diseases

Autori
Martin, Tiphaine C ; Šimurina, Mirna ; Ząbczyńska, Marta ; Martinic Kavur, Marina ; Rydlewska, Magdalena ; Pezer, Marija ; Kozłowska, Kamila ; Burri, Andrea ; Vilaj, Marija ; Turek-Jabrocka, Renata ; Krnjajić- Tadijanović, Milena ; Trofimiuk-Müldner, Małgorzata ; Ugrina, Ivo ; Lityńska, Anna ; Hubalewska-Dydejczyk, Alicja ; Trbojevic- Akmacic, Irena ; Lin, Ee Mun ; Walsh, John P ; Pocheć, Ewa ; Spector, Tim D ; Wilson, Scott G ; Lauc, Gordan

Izvornik
Molecular & cellular proteomics (1535-9476) 2020 (2020); X, 64

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Antibodies ; Antibody-dependent cell-mediated cytotoxicity (ADCC) ; Autoimmune thyroid disease ; Fucosylation ; Glycoproteins ; Glycosylation ; IgG ; Immunology ; Patient cohorts ; Thyroid peroxidase antibodies (TPOAb)

Sažetak
Autoimmune thyroid diseases (AITD) are the most common group of autoimmune diseases, associated with lymphocyte infiltration and the production of thyroid autoantibodies, like thyroid peroxidase antibodies (TPOAb), in the thyroid gland. Immunoglobulins and cell-surface receptors are glycoproteins with distinctive glycosylation patterns that play a structural role in maintaining and modulating their functions. We investigated associations of total circulating IgG and peripheral blood mononuclear cells glycosylation with AITD and the influence of genetic background in a case- control study with several independent cohorts and over 3, 000 individuals in total. The study revealed an inverse association of IgG core fucosylation with TPOAb and AITD, as well as decreased peripheral blood mononuclear cells antennary α1, 2 fucosylation in AITD, but no shared genetic variance between AITD and glycosylation. These data suggest that the decreased level of IgG core fucosylation is a risk factor for AITD that promotes antibody- dependent cell-mediated cytotoxicity previously associated with TPOAb levels.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove
Opća bolnica "Dr. Josip Benčević"

Citiraj ovu publikaciju

Martin, Tiphaine C; Šimurina, Mirna; Ząbczyńska, Marta; Martinic Kavur, Marina; Rydlewska, Magdalena; Pezer, Marija; Kozłowska, Kamila; Burri, Andrea; Vilaj, Marija; Turek-Jabrocka, Renata et al.
Decreased immunoglobulin G core fucosylation, a player in antibody-dependent cell-mediated cytotoxicity, is associated with autoimmune thyroid diseases // Molecular & cellular proteomics, 2020 (2020), x, 64 doi:10.1074/mcp.ra119.001860 (međunarodna recenzija, članak, znanstveni)
Martin, T., Šimurina, M., Ząbczyńska, M., Martinic Kavur, M., Rydlewska, M., Pezer, M., Kozłowska, K., Burri, A., Vilaj, M. & Turek-Jabrocka, R. (2020) Decreased immunoglobulin G core fucosylation, a player in antibody-dependent cell-mediated cytotoxicity, is associated with autoimmune thyroid diseases. Molecular & cellular proteomics, 2020, x, 64 doi:10.1074/mcp.ra119.001860.
@article{article, year = {2020}, pages = {64}, DOI = {10.1074/mcp.ra119.001860}, chapter = {x}, keywords = {Antibodies, Antibody-dependent cell-mediated cytotoxicity (ADCC), Autoimmune thyroid disease, Fucosylation, Glycoproteins, Glycosylation, IgG, Immunology, Patient cohorts, Thyroid peroxidase antibodies (TPOAb)}, journal = {Molecular and cellular proteomics}, doi = {10.1074/mcp.ra119.001860}, volume = {2020}, issn = {1535-9476}, title = {Decreased immunoglobulin G core fucosylation, a player in antibody-dependent cell-mediated cytotoxicity, is associated with autoimmune thyroid diseases}, keyword = {Antibodies, Antibody-dependent cell-mediated cytotoxicity (ADCC), Autoimmune thyroid disease, Fucosylation, Glycoproteins, Glycosylation, IgG, Immunology, Patient cohorts, Thyroid peroxidase antibodies (TPOAb)}, chapternumber = {x} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
  • Scopus
  • MEDLINE


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