engleski

Expression of leucocytes following myocardial infarction is modulated by white wine consumption

A permanent coronary ligation was performed to determine how moderate white wine consumption, with low and high phenolic content, modulates inflammatory cells infiltration of the ischemic myocardium. Male Sprague-Dawley rats were given either a combination of different white wines and water or water only, for 28 days. Following coronary ligation, animals were kept alive for 24 hours. Five areas of myocardial wall were analysed -infarct/ischemic zone, three peri- infarct/border zones and a control/non-ischemic zone -to determine the expression of immunoreactivity for myeloperoxidase (MPO)- neutrophils marker and cluster of differentiation 68 (CD68)- macrophages marker. Significantly smaller expression for both MPO and CD68 was found in all three peri-infarct zones of wine drinking animals (p<0.001). There was no difference in expression of leukocyte markers between animals drinking standard and polyphenol- rich white wine, although for CD68, a non- significant attenuation was noticed in the latter. The wine drinking inflammatory attenuation was comparable to the effect of post- ischemic reperfusion or to the effects of some anti-inflammatory medications. We conclude that white wine consumption positively modulates peri- infarct inflammatory infiltration and we expect that this effect will be conveyed to later phases of infarct healing.

Myocardial infarction ; White wine consumption

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