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Pregled bibliografske jedinice broj: 1048180

Systemic and Local Increase of Granulysin Expression in Cytotoxic Lymphocytes in Severe Psoriasis


Vičić, M; Kaštelan, M; Sotošek Tokmadžić, V; Prpić Massari, L
Systemic and Local Increase of Granulysin Expression in Cytotoxic Lymphocytes in Severe Psoriasis // Acta Dermato Venereologica, 99 (2019), 1136-1142 doi:10.2340/00015555-3298 (međunarodna recenzija, članak, znanstveni)


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Naslov
Systemic and Local Increase of Granulysin Expression in Cytotoxic Lymphocytes in Severe Psoriasis

Autori
Vičić, M ; Kaštelan, M ; Sotošek Tokmadžić, V ; Prpić Massari, L

Izvornik
Acta Dermato Venereologica (0001-5555) 99 (2019); 1136-1142

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
cytotoxicity ; granulysin ; psoriasis ; T lymphocytes.

Sažetak
Psoriasis is considered to be a cytokine-driven immune-mediated disease, although the cell cytotoxicity mechanisms involved remain unrecognized. Herein, we analyzed granulysin expression in different lymphocyte subsets of peripheral blood of 40 psoriatic patients (20 with severe and 20 with mild psoriasis) and seven sample of psoriatic skin. The simultaneous detection of intracellular granulysin and cell surface antigens was performed using flow cytometry in peripheral blood and immunohistochemistry in skin lesions. The frequency of granulysin+ cells, mean fluorescence intensity for granulysin, and the frequency of CD8+ T lymphocytes, NK cells, and NKT cells expressing granulysin molecules in peripheral blood were significantly higher in patients with severe psoriasis compared to mild disease and healthy individuals. These were also correlated with disease severity. Furthermore, granulysin+ cells, CD8+granulysin+ T lymphocytes, and CD56+granulysin+ NK cells were present in a higher frequency in the epidermal basal cell layer and in the dermal infiltrate of lesional skin as compared to non-lesional and healthy skin. In conclusion, granulysin+ cytotoxic cells are upregulated in blood and lesions of patients with psoriasis suggesting the involvement of granulysin mediated cytotoxicity in psoriasis pathogenesis

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove:
Medicinski fakultet, Rijeka,
Klinički bolnički centar Rijeka,
Fakultet zdravstvenih studija u Rijeci

Poveznice na cjeloviti tekst rada:

doi www.medicaljournals.se

Citiraj ovu publikaciju:

Vičić, M; Kaštelan, M; Sotošek Tokmadžić, V; Prpić Massari, L
Systemic and Local Increase of Granulysin Expression in Cytotoxic Lymphocytes in Severe Psoriasis // Acta Dermato Venereologica, 99 (2019), 1136-1142 doi:10.2340/00015555-3298 (međunarodna recenzija, članak, znanstveni)
Vičić, M., Kaštelan, M., Sotošek Tokmadžić, V. & Prpić Massari, L. (2019) Systemic and Local Increase of Granulysin Expression in Cytotoxic Lymphocytes in Severe Psoriasis. Acta Dermato Venereologica, 99, 1136-1142 doi:10.2340/00015555-3298.
@article{article, year = {2019}, pages = {1136-1142}, DOI = {10.2340/00015555-3298}, keywords = {cytotoxicity, granulysin, psoriasis, T lymphocytes.}, journal = {Acta Dermato Venereologica}, doi = {10.2340/00015555-3298}, volume = {99}, issn = {0001-5555}, title = {Systemic and Local Increase of Granulysin Expression in Cytotoxic Lymphocytes in Severe Psoriasis}, keyword = {cytotoxicity, granulysin, psoriasis, T lymphocytes.} }
@article{article, year = {2019}, pages = {1136-1142}, DOI = {10.2340/00015555-3298}, keywords = {cytotoxicity, granulysin, psoriasis, T lymphocytes.}, journal = {Acta Dermato Venereologica}, doi = {10.2340/00015555-3298}, volume = {99}, issn = {0001-5555}, title = {Systemic and Local Increase of Granulysin Expression in Cytotoxic Lymphocytes in Severe Psoriasis}, keyword = {cytotoxicity, granulysin, psoriasis, T lymphocytes.} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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