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Systemic and Local Increase of Granulysin Expression in Cytotoxic Lymphocytes in Severe Psoriasis (CROSBI ID 274802)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Vičić, M ; Kaštelan, M ; Sotošek Tokmadžić, V ; Prpić Massari, L Systemic and Local Increase of Granulysin Expression in Cytotoxic Lymphocytes in Severe Psoriasis // Acta dermato-venereologica, 99 (2019), 1136-1142. doi: 10.2340/00015555-3298

Podaci o odgovornosti

Vičić, M ; Kaštelan, M ; Sotošek Tokmadžić, V ; Prpić Massari, L

engleski

Systemic and Local Increase of Granulysin Expression in Cytotoxic Lymphocytes in Severe Psoriasis

Psoriasis is considered to be a cytokine-driven immune-mediated disease, although the cell cytotoxicity mechanisms involved remain unrecognized. Herein, we analyzed granulysin expression in different lymphocyte subsets of peripheral blood of 40 psoriatic patients (20 with severe and 20 with mild psoriasis) and seven sample of psoriatic skin. The simultaneous detection of intracellular granulysin and cell surface antigens was performed using flow cytometry in peripheral blood and immunohistochemistry in skin lesions. The frequency of granulysin+ cells, mean fluorescence intensity for granulysin, and the frequency of CD8+ T lymphocytes, NK cells, and NKT cells expressing granulysin molecules in peripheral blood were significantly higher in patients with severe psoriasis compared to mild disease and healthy individuals. These were also correlated with disease severity. Furthermore, granulysin+ cells, CD8+granulysin+ T lymphocytes, and CD56+granulysin+ NK cells were present in a higher frequency in the epidermal basal cell layer and in the dermal infiltrate of lesional skin as compared to non-lesional and healthy skin. In conclusion, granulysin+ cytotoxic cells are upregulated in blood and lesions of patients with psoriasis suggesting the involvement of granulysin mediated cytotoxicity in psoriasis pathogenesis

cytotoxicity ; granulysin ; psoriasis ; T lymphocytes.

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o izdanju

99

2019.

1136-1142

objavljeno

0001-5555

10.2340/00015555-3298

Povezanost rada

Kliničke medicinske znanosti

Poveznice
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