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Pregled bibliografske jedinice broj: 1048135

Molecular cytogenetic characterization of two murine cancer cell lines derived from salivary gland


Steinacker, Ralf; Liehr, Thomas; Kosyakova, Nadezda; Rincic, Martina; Azawi, Shaymaa S. Hussein
Molecular cytogenetic characterization of two murine cancer cell lines derived from salivary gland // Biological Communications, 63 (2018), 4; 243-255 doi:10.21638/spbu03.2018.403 (međunarodna recenzija, članak, znanstveni)


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Naslov
Molecular cytogenetic characterization of two murine cancer cell lines derived from salivary gland

Autori
Steinacker, Ralf ; Liehr, Thomas ; Kosyakova, Nadezda ; Rincic, Martina ; Azawi, Shaymaa S. Hussein

Izvornik
Biological Communications (2542-2154) 63 (2018), 4; 243-255

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
salivary gland cancer, neoplastic disease ; dental and oral disease, aCGH

Sažetak
Here two murine salivary gland cancer (SGC) cell lines WR21 and SCA-9 were studied for the first time in detail by high-resolution molecular cytogenetic approaches. This study revealed that these cell lines are models for human SGCs of initial stage myoepithelioid or mucoepidermoid (WR21) and of advanced stage mucoepidermoid (SCA-9) tumors. Besides, three genes most likely playing a role in SGC development (FGF10, ELAVL1/HUR and SEL1) were identified. All of them were involved in translocation events in these in vitro models and thus were most likely activated. Overall, the present study highlights the necessity not only to establish but also to genetically characterize murine tumor cell lines. Without such a characterization they cannot be used in a reasonable way in research.

Izvorni jezik
Engleski



POVEZANOST RADA


Ustanove:
Medicinski fakultet, Zagreb

Profili:

Avatar Url Martina Rinčić (autor)

Poveznice na cjeloviti tekst rada:

doi

Citiraj ovu publikaciju:

Steinacker, Ralf; Liehr, Thomas; Kosyakova, Nadezda; Rincic, Martina; Azawi, Shaymaa S. Hussein
Molecular cytogenetic characterization of two murine cancer cell lines derived from salivary gland // Biological Communications, 63 (2018), 4; 243-255 doi:10.21638/spbu03.2018.403 (međunarodna recenzija, članak, znanstveni)
Steinacker, R., Liehr, T., Kosyakova, N., Rincic, M. & Azawi, S. (2018) Molecular cytogenetic characterization of two murine cancer cell lines derived from salivary gland. Biological Communications, 63 (4), 243-255 doi:10.21638/spbu03.2018.403.
@article{article, year = {2018}, pages = {243-255}, DOI = {10.21638/spbu03.2018.403}, keywords = {salivary gland cancer, neoplastic disease, dental and oral disease, aCGH}, journal = {Biological Communications}, doi = {10.21638/spbu03.2018.403}, volume = {63}, number = {4}, issn = {2542-2154}, title = {Molecular cytogenetic characterization of two murine cancer cell lines derived from salivary gland}, keyword = {salivary gland cancer, neoplastic disease, dental and oral disease, aCGH} }
@article{article, year = {2018}, pages = {243-255}, DOI = {10.21638/spbu03.2018.403}, keywords = {salivary gland cancer, neoplastic disease, dental and oral disease, aCGH}, journal = {Biological Communications}, doi = {10.21638/spbu03.2018.403}, volume = {63}, number = {4}, issn = {2542-2154}, title = {Molecular cytogenetic characterization of two murine cancer cell lines derived from salivary gland}, keyword = {salivary gland cancer, neoplastic disease, dental and oral disease, aCGH} }

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