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Pregled bibliografske jedinice broj: 1047786

The levels of 12 cytokines and growth factors in tears: hyperthyreosis vs euthyreosis


Mandić, Jelena Juri; Kozmar, Ana; Kusačić-Kuna, Sanja; Jazbec, Anamarija; Mandić, Krešimir; Mrazovac, Danijela; Vukojević, Nenad
The levels of 12 cytokines and growth factors in tears: hyperthyreosis vs euthyreosis // Graefe's Archive for Clinical and Experimental Ophthalmology, 256 (2018), 4; 845-852 doi:10.1007/s00417-017-3892-6 (međunarodna recenzija, članak, znanstveni)


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Naslov
The levels of 12 cytokines and growth factors in tears: hyperthyreosis vs euthyreosis

Autori
Mandić, Jelena Juri ; Kozmar, Ana ; Kusačić-Kuna, Sanja ; Jazbec, Anamarija ; Mandić, Krešimir ; Mrazovac, Danijela ; Vukojević, Nenad

Izvornik
Graefe's Archive for Clinical and Experimental Ophthalmology (0721-832X) 256 (2018), 4; 845-852

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Dysfunctional tear syndrome ; Hyperthyroidism ; Ocular surface inflammation ; Tear cytokines ; Thyroid-associated orbitopathy

Sažetak
Abstract PURPOSE: Simultaneous analyses of the contents and ratios of 12 cytokines and growth factors in single samples of human tears were performed, and the results were compared between a group of healthy subjects and a group of patients with Graves' hyperthyreosis (GH) without thyroid-associated orbitopathy (TAO). METHODS: Determinations and concentration measurements of interleukins (IL-2, IL4, IL-6, IL-8, IL-10, IL-1α, and IL-1β) interferon (IFN-γ), tumor necrosis factor (TNF-α), monocyte chemoattractant protein (MCP-1), vascular endothelial growth factor (VEGF), and epidermal growth factor (EGF) were performed with single tear samples from 21 patients with hyperthyreosis and 22 healthy subjects. The analyses were performed using a Randox microchip with an Evidence Biochip Array Analyzer. RESULTS: We found significant differences between the healthy donor group and the hyperthyreosis group in the levels of IL-6, IL-10, VEGF, IL-1α, and MCP-1. The concentration of IL-6 was considerably higher in the hyperthyreosis group, IL-10 was higher in the healthy donor group, and VEGF and MPC-1 were higher in the hyperthyreosis group. The IL-8 and IFN-γ levels were higher in the hyperthyreosis group. The ratios of all of the cytokines to anti-inflammatory IL-10 were significantly elevated in the hyperthyreosis group. CONCLUSION: There are clear differences in the levels of cytokines and growth factors in the tears of healthy subjects and patients with GH without TAO. Tear cytokine changes and related dysfunctional tear syndrome (DTS) could be an early sign of occult TAO in Graves' hyperthyreosis patients.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove:
Klinički bolnički centar Zagreb

doi

Citiraj ovu publikaciju

Mandić, Jelena Juri; Kozmar, Ana; Kusačić-Kuna, Sanja; Jazbec, Anamarija; Mandić, Krešimir; Mrazovac, Danijela; Vukojević, Nenad
The levels of 12 cytokines and growth factors in tears: hyperthyreosis vs euthyreosis // Graefe's Archive for Clinical and Experimental Ophthalmology, 256 (2018), 4; 845-852 doi:10.1007/s00417-017-3892-6 (međunarodna recenzija, članak, znanstveni)
Mandić, J., Kozmar, A., Kusačić-Kuna, S., Jazbec, A., Mandić, K., Mrazovac, D. & Vukojević, N. (2018) The levels of 12 cytokines and growth factors in tears: hyperthyreosis vs euthyreosis. Graefe's Archive for Clinical and Experimental Ophthalmology, 256 (4), 845-852 doi:10.1007/s00417-017-3892-6.
@article{article, year = {2018}, pages = {845-852}, DOI = {10.1007/s00417-017-3892-6}, keywords = {Dysfunctional tear syndrome, Hyperthyroidism, Ocular surface inflammation, Tear cytokines, Thyroid-associated orbitopathy}, journal = {Graefe's Archive for Clinical and Experimental Ophthalmology}, doi = {10.1007/s00417-017-3892-6}, volume = {256}, number = {4}, issn = {0721-832X}, title = {The levels of 12 cytokines and growth factors in tears: hyperthyreosis vs euthyreosis}, keyword = {Dysfunctional tear syndrome, Hyperthyroidism, Ocular surface inflammation, Tear cytokines, Thyroid-associated orbitopathy} }
@article{article, year = {2018}, pages = {845-852}, DOI = {10.1007/s00417-017-3892-6}, keywords = {Dysfunctional tear syndrome, Hyperthyroidism, Ocular surface inflammation, Tear cytokines, Thyroid-associated orbitopathy}, journal = {Graefe's Archive for Clinical and Experimental Ophthalmology}, doi = {10.1007/s00417-017-3892-6}, volume = {256}, number = {4}, issn = {0721-832X}, title = {The levels of 12 cytokines and growth factors in tears: hyperthyreosis vs euthyreosis}, keyword = {Dysfunctional tear syndrome, Hyperthyroidism, Ocular surface inflammation, Tear cytokines, Thyroid-associated orbitopathy} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
  • Scopus
  • MEDLINE


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