Napredna pretraga

Pregled bibliografske jedinice broj: 1047639

Myeloid Cells Restrict MCMV and Drive Stress- Induced Extramedullary Hematopoiesis through STAT1


Gawish, Riem; Bulat, Tanja; Biaggio, Mario; Lassnig, Caroline; Bago-Horvath, Zsuzsanna; Macho-Maschler, Sabine; Poelzl, Andrea; Simonović, Natalija; Prchal-Murphy, Michaela; Rom, Rita et al.
Myeloid Cells Restrict MCMV and Drive Stress- Induced Extramedullary Hematopoiesis through STAT1 // Cell Reports, 26 (2019), 9; 2394-2406 doi:10.1016/j.celrep.2019.02.017 (međunarodna recenzija, članak, znanstveni)


Naslov
Myeloid Cells Restrict MCMV and Drive Stress- Induced Extramedullary Hematopoiesis through STAT1

Autori
Gawish, Riem ; Bulat, Tanja ; Biaggio, Mario ; Lassnig, Caroline ; Bago-Horvath, Zsuzsanna ; Macho-Maschler, Sabine ; Poelzl, Andrea ; Simonović, Natalija ; Prchal-Murphy, Michaela ; Rom, Rita ; Amenitsch, Lena ; Ferrarese, Luca ; Kornhoff, Juliana ; Lederer, Therese ; Svinka, Jasmin ; Eferl, Robert ; Bosmann, Markus ; Kalinke, Ulrich ; Stoiber, Dagmar ; Sexl, Veronika ; Krmpotić, Astrid ; Jonjić, Stipan ; Müller, Mathias ; Strobl, Birgit

Izvornik
Cell Reports (2211-1247) 26 (2019), 9; 2394-2406

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Monocytes signal transducer and activator of transcription Herpesviridae IFN-I receptor IFN-II receptor L-27 receptor TLR9 agonist
(Monocytes signal transducer and activator of transcription Herpesviridae IFN-I receptor IFN-II receptor IL-27 receptor TLR9 agonist)

Sažetak
Cytomegalovirus (CMV) has a high prevalence worldwide, is often fatal for immunocompromised patients, and causes bone marrow suppression. Deficiency of signal transducer and activator of transcription 1 (STAT1) results in severely impaired antiviral immunity. We have used cell- type restricted deletion of Stat1 to determine the importance of myeloid cell activity for the defense against murine CMV (MCMV). We show that myeloid STAT1 limits MCMV burden and infection- associated pathology in the spleen but does not affect ultimate clearance of infection. Unexpectedly, we found an essential role of myeloid STAT1 in the induction of extramedullary hematopoiesis (EMH). The EMH- promoting function of STAT1 was not restricted to MCMV infection but was also observed during CpG oligodeoxynucleotide-induced sterile inflammation. Collectively, we provide genetic evidence that signaling through STAT1 in myeloid cells is required to restrict MCMV at early time points post-infection and to induce compensatory hematopoiesis in the spleen.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Ustanove
Medicinski fakultet, Rijeka

Citiraj ovu publikaciju

Gawish, Riem; Bulat, Tanja; Biaggio, Mario; Lassnig, Caroline; Bago-Horvath, Zsuzsanna; Macho-Maschler, Sabine; Poelzl, Andrea; Simonović, Natalija; Prchal-Murphy, Michaela; Rom, Rita et al.
Myeloid Cells Restrict MCMV and Drive Stress- Induced Extramedullary Hematopoiesis through STAT1 // Cell Reports, 26 (2019), 9; 2394-2406 doi:10.1016/j.celrep.2019.02.017 (međunarodna recenzija, članak, znanstveni)
Gawish, R., Bulat, T., Biaggio, M., Lassnig, C., Bago-Horvath, Z., Macho-Maschler, S., Poelzl, A., Simonović, N., Prchal-Murphy, M. & Rom, R. (2019) Myeloid Cells Restrict MCMV and Drive Stress- Induced Extramedullary Hematopoiesis through STAT1. Cell Reports, 26 (9), 2394-2406 doi:10.1016/j.celrep.2019.02.017.
@article{article, year = {2019}, pages = {2394-2406}, DOI = {10.1016/j.celrep.2019.02.017}, keywords = {monocytes signal transducer and activator of transcription Herpesviridae IFN-I receptor IFN-II receptor IL-27 receptor TLR9 agonist}, journal = {Cell Reports}, doi = {10.1016/j.celrep.2019.02.017}, volume = {26}, number = {9}, issn = {2211-1247}, title = {Myeloid Cells Restrict MCMV and Drive Stress- Induced Extramedullary Hematopoiesis through STAT1}, keyword = {monocytes signal transducer and activator of transcription Herpesviridae IFN-I receptor IFN-II receptor IL-27 receptor TLR9 agonist} }

Citati