Technological Advances in Preclinical Drug Evaluation: the Role of –Omics Methods (CROSBI ID 274588)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Kraljević Pavelić, Sandra ; Markova-Car, Elitza ; Klobučar, Marko ; Sappe, Lana ; Spaventi, Radan
engleski
Technological Advances in Preclinical Drug Evaluation: the Role of –Omics Methods
Preclinical drug development is an essential step in the drug development process where evaluation of new chemical entities occurs. In particular, preclinical drug development phases include deep analysis of drug candidates' interactions with biomolecules/targets, their safety, toxicity, pharmacokinetics, metabolism by use of assays in vitro and in vivo animal assays. Legal aspects of the required procedures are well-established. Herein we present a comprehensive summary of current state-of the art approaches and techniques used in preclinical studies. In particular, we will review the potential of new, -omics methods and platforms for mechanistic evaluation of drug candidates and speed-up of the preclinical evaluation steps.
drug testing ; proteomics ; transcriptomics ; mass spectrometry
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Podaci o izdanju
26 (29)
2019.
1-13
objavljeno
0929-8673
1875-533X
10.2174/0929867326666190711122819
Povezanost rada
Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje), Temeljne medicinske znanosti