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Serum catestatin levels in obese children and adolescents

The obesity in population of children and adolescents is one of the biggest public health problems in word today. Early childhood obesity with cluster of metabolic disorders (insulin resistance, impaired glucose tolerance, dyslipidemia and hypertension) are risk factor for cardiovascular morbidly and mortality later in life. Catestatin is a Chromogranin A derived peptide which reduces hepatic/plasma lipids, plasma insulin, improves insulin sensitivity, reduces hypertension and inhibits obesity in murine models. In humans, there were few studies published witch showed level of catestatin is significant risk factor for hypertension in adult patients. To our knowledge, this the first report of serum level of catestatin in obese children and adolescents.

adolescents, catestatin, children, metabolic syndrome, obesity

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