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Pregled bibliografske jedinice broj: 104705

Curcumin - A Potent Inhibitor of Galectin-3 Expression


Dumić, Jerka; Dabelić, Sanja; Flögel, Mirna
Curcumin - A Potent Inhibitor of Galectin-3 Expression // Food technology and biotechnology, 40 (2002), 4; 281-287 (međunarodna recenzija, članak, znanstveni)


Naslov
Curcumin - A Potent Inhibitor of Galectin-3 Expression

Autori
Dumić, Jerka ; Dabelić, Sanja ; Flögel, Mirna

Izvornik
Food technology and biotechnology (1330-9862) 40 (2002), 4; 281-287

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
galectin-3; curcumin; alkylatingagent MNNG; UV light

Sažetak
The expression of galectin-3, a P-galactoside binding lectin, was found to be affected by different kinds of stressors, and is strongly modified in numerous physiological and pathophysiological conditions. Although no precise regulatory mechanisms of galectin-3 expression are unraveled, transcription factors AP-1 (activator protein 1) and NF-kappaB (nuclear factor kappa B) play an important role. in these processes. Activities of both transcription factors are affected by curcumin, a biologically active compound extracted from rhizomes of Curcuma species. We have analyzed the impact of curcumin on the expression of galectin-3 in glioblastoma cells under basal conditions and under stress invoked by the cell exposure to alkylating agent N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and ultraviolet C (UV-C) light. Galectin-3 level was measured by western-blot technique using M3/38 monoclonal antibody. Curcumin has decreased the basal level of galectin-3, while the pretreatment of cells with curcumin has considerably reduced the inducible effect of UV-C radiation and abolished the inducible effect of alkylating agent. Thus, curcumin has been identified as a potent inhibitor of galectin-3 expression.

Izvorni jezik
Engleski

Znanstvena područja
Biologija



POVEZANOST RADA


Projekt / tema
0006611
006320

Ustanove
Farmaceutsko-biokemijski fakultet, Zagreb

Profili:

Avatar Url Jerka Dumić (autor)

Avatar Url Sanja Dabelić (autor)

Avatar Url Mirna Flogel-Mršić (autor)

Citiraj ovu publikaciju

Dumić, Jerka; Dabelić, Sanja; Flögel, Mirna
Curcumin - A Potent Inhibitor of Galectin-3 Expression // Food technology and biotechnology, 40 (2002), 4; 281-287 (međunarodna recenzija, članak, znanstveni)
Dumić, J., Dabelić, S. & Flögel, M. (2002) Curcumin - A Potent Inhibitor of Galectin-3 Expression. Food technology and biotechnology, 40 (4), 281-287.
@article{article, year = {2002}, pages = {281-287}, keywords = {galectin-3, curcumin, alkylatingagent MNNG, UV light}, journal = {Food technology and biotechnology}, volume = {40}, number = {4}, issn = {1330-9862}, title = {Curcumin - A Potent Inhibitor of Galectin-3 Expression}, keyword = {galectin-3, curcumin, alkylatingagent MNNG, UV light} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


Uključenost u ostale bibliografske baze podataka:


  • Biological Abstracts
  • Chemical Abstracts
  • SCIexp