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Is central corneal thickness a risk factor for pseudoexfoliation glaucoma?

The aim of the study was to compare central corneal thickness measurements among patients with pseudoexfoliation glaucoma, primary open angle glaucoma, and normal subjects. The study included 60 eyes divided into three groups: group 1 of 24 eyes pseudoexfoliation glaucoma ; group 2 of 20 eyes with primary open angle glaucoma ; and group 3 of 16 normal eyes. Central corneal thickness was measured using an ultrasound pachymeter, and intraocular pressure was measured by use of applanation tonometer. Statistical methods were employed on between-group comparison of the values obtained by central corneal thickness measurement. The mean central corneal thickness was similar across the three study groups, with no statistically significant difference among normal eyes, open angle glaucoma eyes and pseudoexfoliation glaucoma eyes (mean ± SD: 570±40, 558±41 and 564±25 mm, respectively). Accordingly, central cornea was not thinner in patients with pseudoexfoliation glaucoma than in either normal subjects or patients with open angle glaucoma. However, the possibility of differences that may have emerged in case of a larger sample size should also be taken in consideration. In conclusion, central corneal thickness was not demonstrated to be a risk factor for the development of pseudoexfoliation glaucoma in our patient series.

Intraocular Pressure | Eye | Corneal biomechanics

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