engleski

CSF tau proteins in evaluation of patients with suspected dementia

The cerebrospinal fluid (CSF) levels of phosphorylated tau proteins reflect the phosphorylation state of tau in the brain. Different tau phosphoepitopes can be sensitively detected in CSF. We evaluated the diagnostic value of CSF total tau protein (t-tau), tau protein phosphorylated at threonine 181, 199 and 231 (p-tau-181, p-tau-199, p-tau-231) in early onset Alzheimer disease (AD) in patients with clinical diagnosis of MCI (mild cognitive impairment), probable and possible AD, as well as nondemented controls included in the study. CSF levels of t-tau, p-tau-181, p-tau-199, p-tau-231 were measured using commercially available ELISA kits (Invitrogen-Biosource, Camarillo, CA, USA). Mean CSF t-tau and CSF p-tau-181 levels were significantly elevated in AD patients compared to MCI and control subjects.

Alzheimer's disease ; cerebrospinal fluid ; mild cognitive impairment ; tau proteins ; ELISA ; early diagnosis

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