hrvatski

Promjene u prikazu središnjeg živčanog sustava u kompjuteriziranoj tomografiji emisijom jednog fotona u oboljelih od posttraumatskog stresnog poremećaja s povećanom agresivnošću

Posttraumatic stress disorder (PTSD) develops after exposure to an extreme traumatic event. Contemporary neurophysiologic understandings describe a prolonged fear reaction, continuing even after a stressor has been extinguished, as a basis of PTSD. The central processing part of this system are the extended amygdala. Disturbances in the extended amygdala can cause inadequate emotional responses to outer stimuli, sucha as exaggerated defensive reactions-impulsive aggression. The aim of this research was to establish possible neurobiological correlates of such disturbances in SPECT functional brain images. For this purpose we selected two groups of PTSD patients. One group (n=25) with manifest impulsive aggression and the other (n=25 without. Differences in brain SPECT findings between the groups were found only for the projection area of extended amygdala, presenting blood hyperperfusion in the region in the dominant brain hemisphere. In the group with manifest impulsive aggression the finding was found in 16 of 25 subjects and in the group without manifest umpulsive aggression in 0 of 25 subjects. Differences between the groups for any other region were not found. our findings are corresponding to those of other similar research and the contemporary neurophysiologic understanding of PTSD and emotions. We, thus, beleive that the hyperperfusion in the region of extended amygdala can be associated with the symptoms of manifest impulsive aggression in our subjects.

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nije evidentirano