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Pregled bibliografske jedinice broj: 1044340

Inherited thrombophilia associated with ischemic paediatric stroke in parents-child pairs


Leniček Krleža, Jasna; Coen Herak, Desiree; Čeri, Andrea; Zadro, Renata; Đuranović, Vlasta
Inherited thrombophilia associated with ischemic paediatric stroke in parents-child pairs // 26th Anniversary International Congress on Thrombosis Abstract Book
Atena, Grčka, 2019. str. 43-43 (poster, međunarodna recenzija, sažetak, znanstveni)


CROSBI ID: 1044340 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Inherited thrombophilia associated with ischemic paediatric stroke in parents-child pairs

Autori
Leniček Krleža, Jasna ; Coen Herak, Desiree ; Čeri, Andrea ; Zadro, Renata ; Đuranović, Vlasta

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
26th Anniversary International Congress on Thrombosis Abstract Book / - , 2019, 43-43

Skup
26th Anniversary International Congress on Thrombosis

Mjesto i datum
Atena, Grčka, 19-22.06.2019

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
inherited thrombophilia ; ischemic pediatric stroke ; cerebral sinovenous thrombosis

Sažetak
Background: Inherited thrombophilia in parents-child pairs with ischemic pediatric stroke (IPS) has been investigated in few studies and included the most common polymorphisms (FV Leiden, FII G20210A, MTHFR C677T, MTHFR A1298C) only. Aims: We aimed to examine inherited thrombophilia frequencies, focusing on previously not investigated polymorphisms, in children with IPS and their parents. Methods: The study included 32 pairs of children with IPS (22 with perinatal, 8 with childhood arterial ischemic stroke and 2 with cerebral sinovenous thrombosis) and their parents (26 mother- child, 1 father-child and 5 both parents-child pairs). Genotyping of FV Leiden, FV HR2, FII G20210A, β-fibrinogen-455G>A, FXIII-A Val34Leu, PAI-1 4G/5G, HPA-1, MTHFR C677T, MTHFR A1298C, ACE I/D and apo E ε2-4 was performed using CVD Strip assay (ViennaLab, Austria). Results: Most frequently identified thrombophilia’s were PAI- 1 4G/5G and ACE I/D both in children and their parents. Similarly, in about half of cases, MTHFR C677T, MTHFR A1298C and FXIII-A Val34Leu frequencies were also found both in children and their parents. β-fibrinogen -455A allele was found in all fathers, half of children and a third of mothers. All frequencies are presented in Figure 1. Conclusions: The high rate of PAI-1 4G/5G and ACE I/D found both in children and their parents suggests that these polymorphisms could play a role in IPS. For FXIII-A Val34Leu and β- fibrinogen-455G>A, further investigation are needed.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
HRZZ-IP-2014-09-2047 - Genski polimorfizmi i ishemijski moždani udar u djece (GENESTROKE) (HRZZ - 2014-09) ( POIROT)

Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb,
Klinički bolnički centar Zagreb,
Klinika za dječje bolesti


Citiraj ovu publikaciju

Leniček Krleža, Jasna; Coen Herak, Desiree; Čeri, Andrea; Zadro, Renata; Đuranović, Vlasta
Inherited thrombophilia associated with ischemic paediatric stroke in parents-child pairs // 26th Anniversary International Congress on Thrombosis Abstract Book
Atena, Grčka, 2019. str. 43-43 (poster, međunarodna recenzija, sažetak, znanstveni)
Leniček Krleža, J., Coen Herak, D., Čeri, A., Zadro, R. & Đuranović, V. (2019) Inherited thrombophilia associated with ischemic paediatric stroke in parents-child pairs. U: 26th Anniversary International Congress on Thrombosis Abstract Book.
@article{article, year = {2019}, pages = {43-43}, keywords = {inherited thrombophilia, ischemic pediatric stroke, cerebral sinovenous thrombosis}, title = {Inherited thrombophilia associated with ischemic paediatric stroke in parents-child pairs}, keyword = {inherited thrombophilia, ischemic pediatric stroke, cerebral sinovenous thrombosis}, publisherplace = {Atena, Gr\v{c}ka} }
@article{article, year = {2019}, pages = {43-43}, keywords = {inherited thrombophilia, ischemic pediatric stroke, cerebral sinovenous thrombosis}, title = {Inherited thrombophilia associated with ischemic paediatric stroke in parents-child pairs}, keyword = {inherited thrombophilia, ischemic pediatric stroke, cerebral sinovenous thrombosis}, publisherplace = {Atena, Gr\v{c}ka} }




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