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Pregled bibliografske jedinice broj: 1044144

GIRK1 triggers multiple cancer-related pathways in the benign mammary epithelial cell line MCF10A


Schratter, Gebhard; Scheruebel, Susanne; Langthaler, Sonja; Ester, Katja; Pelzmann, Brigitte; Ghaffari-Tabrizi-Wizsy, Nassim; Rezania, Simin; Gorischek, Astrid; Platzer, Dieter; Zorn- Pauly, Klaus et al.
GIRK1 triggers multiple cancer-related pathways in the benign mammary epithelial cell line MCF10A // Scientific reports, 9 (2019), 19277, 18 doi:10.1038/s41598-019-55683-w (međunarodna recenzija, članak, znanstveni)


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Naslov
GIRK1 triggers multiple cancer-related pathways in the benign mammary epithelial cell line MCF10A

Autori
Schratter, Gebhard ; Scheruebel, Susanne ; Langthaler, Sonja ; Ester, Katja ; Pelzmann, Brigitte ; Ghaffari-Tabrizi-Wizsy, Nassim ; Rezania, Simin ; Gorischek, Astrid ; Platzer, Dieter ; Zorn- Pauly, Klaus ; Ahammer, Helmut ; Prokesch, Andreas ; Stanzer, Stefanie ; Devaney, Trevor T. J. ; Schmidt, Kurt ; Jahn, Stephan W. ; Prassl, Ruth ; Bauernhofer Thomas ; Schreibmayer, Wolfgang

Izvornik
Scientific reports (2045-2322) 9 (2019); 19277, 18

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
GIRK1 ; breast cancer ; MCF10A ; MCF7

Sažetak
Excessive expression of subunit 1 of GIRK1 in ER+ breast tumors is associated with reduced survival times and increased lymph node metastasis in patients. To investigate possible tumor-initiating properties, benign MCF10A and malign MCF7 mammary epithelial cells were engineered to overexpress GIRK1 neoplasia associated vital parameters and resting potentials were measured and compared to controls. The presence of GIRK1 resulted in resting potentials negative to the controls. Upon GIRK1 overexpression, several cellular pathways were regulated towards pro-tumorigenic action as revealed by comparison of transcriptomes of MCF10AGIRK1 with the control (MCF10AeGFP). According to transcriptome analysis, cellular migration was promoted while wound healing and extracellular matrix interactions were impaired. Vital parameters in MCF7 cells were affected akin the benign MCF10A lines, but to a lesser extent. Thus, GIRK1 regulated cellular pathways in mammary epithelial cells are likely to contribute to the development and progression of breast cancer

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti



POVEZANOST RADA


Ustanove:
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Katja Ester (autor)

Citiraj ovu publikaciju

Schratter, Gebhard; Scheruebel, Susanne; Langthaler, Sonja; Ester, Katja; Pelzmann, Brigitte; Ghaffari-Tabrizi-Wizsy, Nassim; Rezania, Simin; Gorischek, Astrid; Platzer, Dieter; Zorn- Pauly, Klaus et al.
GIRK1 triggers multiple cancer-related pathways in the benign mammary epithelial cell line MCF10A // Scientific reports, 9 (2019), 19277, 18 doi:10.1038/s41598-019-55683-w (međunarodna recenzija, članak, znanstveni)
Schratter, G., Scheruebel, S., Langthaler, S., Ester, K., Pelzmann, B., Ghaffari-Tabrizi-Wizsy, N., Rezania, S., Gorischek, A., Platzer, D. & Zorn- Pauly, K. (2019) GIRK1 triggers multiple cancer-related pathways in the benign mammary epithelial cell line MCF10A. Scientific reports, 9, 19277, 18 doi:10.1038/s41598-019-55683-w.
@article{article, year = {2019}, pages = {18}, DOI = {10.1038/s41598-019-55683-w}, chapter = {19277}, keywords = {GIRK1, breast cancer, MCF10A, MCF7}, journal = {Scientific reports}, doi = {10.1038/s41598-019-55683-w}, volume = {9}, issn = {2045-2322}, title = {GIRK1 triggers multiple cancer-related pathways in the benign mammary epithelial cell line MCF10A}, keyword = {GIRK1, breast cancer, MCF10A, MCF7}, chapternumber = {19277} }
@article{article, year = {2019}, pages = {18}, DOI = {10.1038/s41598-019-55683-w}, chapter = {19277}, keywords = {GIRK1, breast cancer, MCF10A, MCF7}, journal = {Scientific reports}, doi = {10.1038/s41598-019-55683-w}, volume = {9}, issn = {2045-2322}, title = {GIRK1 triggers multiple cancer-related pathways in the benign mammary epithelial cell line MCF10A}, keyword = {GIRK1, breast cancer, MCF10A, MCF7}, chapternumber = {19277} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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