Reproductive ability of pubertal male and female rats (CROSBI ID 98342)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Zemunik, Tatijana ; Peruzović, Marijana ; Čapkun , Vesna ; Zekan, Ljubinka ; Tomić, Snježana ; Milković, Karmela
engleski
Reproductive ability of pubertal male and female rats
Ten Fisher rats 50 and 55 days of age made up the pubertal group, and ten rats 90 and 95 days of age served as the controls. The testicular and epididymal weights and volumes of the pubertal males were lower than those of the controls (p<0.001). There was also a difference in the relative epididymal weight (p<0.001). The sperm of pubertal males was morphologically abnormal in 58.2% of cases, as opposed to only 3.8% in the controls (p<0.001). The mean number of spermatozoa in the control group was 11.9×106/ml and their viability was 99.6%, while these values could not be determined for pubertal rats. Serum testosterone was higher in the pubertal animals than in the controls (2.52 ± 1.46 vs. 0.92 ± 0.34 nM, p<0.01). The ovaries of control females were heavier than those of pubertal females (p<0.001) but there was no difference in their relative weights. Serum estradiol was similar in both groups (75.5 ± 12.8 vs. 81.8 ± 14.7 nM, p>0.05). At the beginning of gestation, the pubertal dams weighed less than the controls (p<0.001) but following uterectomy the body weights were equal. Pubertal dams delivered fewer pups than the controls (8.1 ± 2.5 vs. 10.4 ± 1.3, p<0.05). There was no difference in the body weights of their offspring or in the weights of their placentas. The results suggest that, in contrast to their female counterparts, pubertal male rats are not fully mature and have not reached complete reproductive capacity at 50-55 days of age.
puberty; reproduction; gonads; sex hormones; pregnancy
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Podaci o izdanju
Povezanost rada
Temeljne medicinske znanosti