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Pregled bibliografske jedinice broj: 1043324

Incidence of diabetes mellitus type 2 in the European population chronically exposed to arsenic


Barbir, Rinea; Michalke, Bernhard; Lucio, Marianna; Tariba, Blanka; Vučić Lovrenčić, Marijana; Šerić, Vatroslav; Canecki-Varžić, Silvija; Ljubić, Spomenka; Smirčić Duvnjak, Lea; Krivohvalek, Adela; Vinković Vrček, Ivana
Incidence of diabetes mellitus type 2 in the European population chronically exposed to arsenic // Clinica Chimica Acta
Barcelona, Španjolska, 2019. str. S306-S307 doi:10.1016/j.cca.2019.03.632 (poster, međunarodna recenzija, sažetak, znanstveni)


CROSBI ID: 1043324 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Incidence of diabetes mellitus type 2 in the European population chronically exposed to arsenic

Autori
Barbir, Rinea ; Michalke, Bernhard ; Lucio, Marianna ; Tariba, Blanka ; Vučić Lovrenčić, Marijana ; Šerić, Vatroslav ; Canecki-Varžić, Silvija ; Ljubić, Spomenka ; Smirčić Duvnjak, Lea ; Krivohvalek, Adela ; Vinković Vrček, Ivana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Clinica Chimica Acta / - , 2019, S306-S307

Skup
EuroMedLab 2019

Mjesto i datum
Barcelona, Španjolska, 19-23.05.2019

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
arsenic exposure, diabetes mellitus

Sažetak
Background-aim: Higher concentrations of arsenic in drinking water has been already reported to be associated with an increased risk of developing diabetes. This study aimed to investigate the association of arsenic levels in urine and blood with insulin resistance (HOMAIR), diabetes parameters (HbA1c, fasting glucose) and diabetes complications (albuminuria). For the first time, comparison of arsenic levels in diabetic vs. healthy populations from Eastern and Western Croatian regions was performed. Methods: A total of 113 participants from Zagreb, Western Croatia, and 80 participants from Slavonia, Eastern Croatia, aged between 25 and 60 years, were included in this study. All participants have signed informed consent. Blood parameters were determined in the clinical laboratories using different biochemical methods on AU680, Beckman Coulter, Brea, USA. Inductively coupled plasma-sectorfield-mass spectrometry (ICPsf-MS, Element II, Thermo Scientific Bremen, Germany) was used to determine total arsenic in blood and urine. In addition, arsenic species. i.e. monomethylarsonate, dimethylarsinate and arsenate, in urine were evaluated by ion exchange chromatography with ICP-sf-MS. Results: Statistical analysis has shown the existence of statistically significant differences for total urine As and As species between Eastern and Western region (pb0.0001). However, most arsenic in the urine of Western region patients was of organic origin, i.e. arsenobetain. Total As and As species in urine were positively correlated with HbA1c values and negatively correlated with albuminuria (pb0.05). For associating arsenic species with HOMAIR and HOMA %B parameters, we used regression analysis, but results were not statistically significant. However, the results for arsenate and dimethylarsinate showed trends with p-values, p=0.067 and p=0.052, respectively. Conclusions: In conclusion, inorganic arsenic, which originates from drinking water, was present mostly in the urine of patients from Eastern Croatian region. Obtained results indicate that inorganic arsenic contributes to the increased risk for diabetes, but not for development of diabetic nephropathy. This study is preliminary in character and further research on the consequences of arsenic exposure for the incidence of diabetes is needed.

Izvorni jezik
Engleski

Poveznice na cjeloviti tekst rada:

doi reader.elsevier.com

Citiraj ovu publikaciju:

Barbir, Rinea; Michalke, Bernhard; Lucio, Marianna; Tariba, Blanka; Vučić Lovrenčić, Marijana; Šerić, Vatroslav; Canecki-Varžić, Silvija; Ljubić, Spomenka; Smirčić Duvnjak, Lea; Krivohvalek, Adela; Vinković Vrček, Ivana
Incidence of diabetes mellitus type 2 in the European population chronically exposed to arsenic // Clinica Chimica Acta
Barcelona, Španjolska, 2019. str. S306-S307 doi:10.1016/j.cca.2019.03.632 (poster, međunarodna recenzija, sažetak, znanstveni)
Barbir, R., Michalke, B., Lucio, M., Tariba, B., Vučić Lovrenčić, M., Šerić, V., Canecki-Varžić, S., Ljubić, S., Smirčić Duvnjak, L., Krivohvalek, A. & Vinković Vrček, I. (2019) Incidence of diabetes mellitus type 2 in the European population chronically exposed to arsenic. U: Clinica Chimica Acta doi:10.1016/j.cca.2019.03.632.
@article{article, author = {Barbir, Rinea and Michalke, Bernhard and Lucio, Marianna and Tariba, Blanka and Vu\v{c}i\'{c} Lovren\v{c}i\'{c}, Marijana and \v{S}eri\'{c}, Vatroslav and Canecki-Var\v{z}i\'{c}, Silvija and Ljubi\'{c}, Spomenka and Smir\v{c}i\'{c} Duvnjak, Lea and Krivohvalek, Adela and Vinkovi\'{c} Vr\v{c}ek, Ivana}, year = {2019}, pages = {S306-S307}, DOI = {10.1016/j.cca.2019.03.632}, keywords = {arsenic exposure, diabetes mellitus}, doi = {10.1016/j.cca.2019.03.632}, title = {Incidence of diabetes mellitus type 2 in the European population chronically exposed to arsenic}, keyword = {arsenic exposure, diabetes mellitus}, publisherplace = {Barcelona, \v{S}panjolska} }
@article{article, author = {Barbir, Rinea and Michalke, Bernhard and Lucio, Marianna and Tariba, Blanka and Vu\v{c}i\'{c} Lovren\v{c}i\'{c}, Marijana and \v{S}eri\'{c}, Vatroslav and Canecki-Var\v{z}i\'{c}, Silvija and Ljubi\'{c}, Spomenka and Smir\v{c}i\'{c} Duvnjak, Lea and Krivohvalek, Adela and Vinkovi\'{c} Vr\v{c}ek, Ivana}, year = {2019}, pages = {S306-S307}, DOI = {10.1016/j.cca.2019.03.632}, keywords = {arsenic exposure, diabetes mellitus}, doi = {10.1016/j.cca.2019.03.632}, title = {Incidence of diabetes mellitus type 2 in the European population chronically exposed to arsenic}, keyword = {arsenic exposure, diabetes mellitus}, publisherplace = {Barcelona, \v{S}panjolska} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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