Low energy optical excitations as an indicator of structural changes initiated at the termini of amyloid proteins (CROSBI ID 273400)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Jong, Kwang Hyok ; Azar, Yavar T. ; Grisanti, Luca ; Stephens, Amberley D. ; Jones, Saul T. E. ; Credgington, Dan ; Kaminski Schierle, Gabriele S. ; Hassanali, Ali
engleski
Low energy optical excitations as an indicator of structural changes initiated at the termini of amyloid proteins
There is a growing body of experimental work showing that protein aggregates associated with amyloid fibrils feature intrinsic fluorescence. In order to understand the microscopic origin of this behavior observed in non-aromatic aggregates of peptides and proteins, we conducted a combined experimental and computational study on the optical properties of amyloid-derived oligopeptides in the near-UV region. We have focused on a few model systems having charged termini (zwitterionic) or acetylated termini. For the zwitterionic system, we were able to simulate the longer tail absorption in the near UV (250–350 nm), supporting the experimental results in terms of excitation spectra. We analyzed the optical excitations responsible for the low-energy absorption and found a large role played by charge-transfer states around the termini. These charge-transfer excitations are very sensitive to the conformation of the peptide and in realistic fibrils may involve inter and intra chain charge reorganization.
amyloid ; optical properties ; protein aggregates ; excited state
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Podaci o izdanju
21 (43)
2019.
23931-23942
objavljeno
1463-9076
1463-9084
10.1039/c9cp04648h